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Graphene based biosensors for healthcare

Published online by Cambridge University Press:  16 May 2017

Trupti Terse-Thakoor ,
Sushmee Badhulika  and
Ashok Mulchandani
Trupti Terse-Thakoor*
Affiliation:
Department of Bioengineering, University of California, Riverside, California 92521, USA
Sushmee Badhulika
Affiliation:
Department of Electrical Engineering, Indian Institute of Technology, 502285 Hyderabad, India
Ashok Mulchandani*
Affiliation:
Department of Chemical & Environmental Engineering, University of California, Riverside, California 92521, USA
*
a) Address all correspondence to these authors. e-mail: tters001@ucr.edu
b) e-mail: adani@engr.ucr.edu
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Abstract

Graphene due to its unique physicochemical properties mainly its large surface to volume ratio, excellent thermal and electrical conductivity, biocompatibility, as well as broad electrochemical potential, has received considerable attention for biosensing applications. In this review paper, we provide a comprehensive overview of the recent advances in the field of electrochemical biosensors developed using the graphene nanomaterial including graphene oxide, reduced graphene oxide, CVD graphene, and various graphene based nanostructures including nanomesh, nanowalls, etc. in healthcare related applications. The review focusses on material synthesis, device fabrication, and biofunctionalization of graphene electrodes in biosensing such as those based on electrochemical impedance, amperometry/voltammetry, potentiometry, conductometry, and field effect transistor. Additionally, several ingenious biosensing strategies of graphene biosensor in clinical diagnosis for detection of proteins (disease biomarkers), nucleic acids (mutation analysis in genetic diseases), small molecules (disease metabolites like glucose, lactic acid etc.), and pathogens (bacterial and viral infections) have also been discussed.

Keywords

nanostructurebiomedicalsensor
Type
Invited Reviews
Information
Journal of Materials Research , Volume 32 , Issue 15: Focus Issue: Two-Dimensional Nanomaterials for Biosensors , 14 August 2017 , pp. 2905 - 2929
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Copyright
Copyright © Materials Research Society 2017 

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Footnotes

Contributing Editor: Venkatesan Renugopalakrishnan

This section of Journal of Materials Research is reserved for papers that are reviews of literature in a given area.

References

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