Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-14T10:53:32.021Z Has data issue: false hasContentIssue false
  • English
  • Français

In vitro study of electron beam deposited calcium phosphate coating in simulated body fluid

Published online by Cambridge University Press:  03 March 2011

M. Hamdi ,
Ari Ide-Ektessabi  and
J.A. Toque
M. Hamdi*
Affiliation:
Department of Engineering Design and Manufacture, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
Ari Ide-Ektessabi
Affiliation:
International Innovation Center, Kyoto University, Sakyo-ku, 606-850 Kyoto, Japan
J.A. Toque
Affiliation:
Department of Engineering Design and Manufacture, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
*
a) Address all correspondence to this author. e-mail: hamdi@um.edu.my
Get access

Abstract

Calcium phosphate coatings prepared using the technique of electron beam deposition were immersed in a simulated body fluid for different periods of time to determine their response in vitro. The amorphous as-deposited coatings dissolved completely after a few days of immersion. After annealing in air at 700 °C, the dissolution of a small amount of amorphous phase in the crystalline coatings promotes the precipitation of bonelike apatite on the recessed regions by increasing the local supersaturation of calcium and phosphate ions. Formation of apatite was confirmed by the x-ray diffraction peaks at (200), (211), and (203) planes which grew after immersion in simulated body fluid. Fourier transform infrared results conformed to this with the increase in intensity of the absorption band at 1450 cm−1, signifying the increase in carbonate content. Scanning electron microscopy results showed spherical-shaped apatite nucleated on dissolved surface after 8 days of immersion. Sixteen days after immersion, almost 80% of the surface area was covered with apatite formation and grew to coalesce between neighboring particles forming an integrated platelike layer after 28 days. No obvious detachment between the grown layer and the underlying coating was observed.

Keywords

CoatingPhysical vapor deposition (PVD)Thin film
Type
Articles
Information
Journal of Materials Research , Volume 22 , Issue 3 , March 2007 , pp. 621 - 626
Copyright
Copyright © Materials Research Society 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1Jansen, J.A., van der Waerden, J.P.C.M., van der Lubbe, H.B.M., and de Groot, K.: Tissue response to percutaneous implants in rabbits. J. Biomed. Mater. Res. 24, 295 (1990).CrossRefGoogle ScholarPubMed
2Jansen, J.A., van der Waerden, J.P.C.M., Wolke, J.G.C., and de Groot, K.: Histologic evaluation of the osseous adaptation to titanium and hydroxyapatite-coated titanium implants. J. Biomed. Mater. Res. 25, 973 (1991).CrossRefGoogle ScholarPubMed
3Jarcho, M.: Calcium phosphate ceramics as hard tissue prosthetics. Clin. Orthop. 157, 259 (1981).CrossRefGoogle Scholar
4Daculsi, G., Le Geros, R.Z., Nevy, E., Lynch, K., and Kerebel, B.: Transformation of biphasic calcium phosphate ceramics in vivo: Ultrastructural and physicochemical characterization. J. Biomed. Mater. Res. 23, 883 (1989).CrossRefGoogle ScholarPubMed
5Ducheyne, P. and Cuckler, J.: Bioactive ceramic prosthetic coatings. Clin. Orthop. 276, 102 (1992).CrossRefGoogle Scholar
6Leeuwenburgh, S., Layrolle, P., Barrère, F., de Bruijn, J., Schoonman, J., van Blitterswijk, C.A., and de Groot, K.: Osteoclastic resorption of biomimetic calcium phosphate coatings in vitro. J. Biomed. Mater. Res. 52, 208 (2001).3.0.CO;2-R>CrossRefGoogle Scholar
7Hyakuna, K., Yamamuro, T., Kotoura, Y., Kakutani, Y., Kitsugi, T., Tagagi, H., Oka, M., and Kokubo, T.: Surface reactions of calcium phosphate ceramics to various solutions. J. Biomed. Mater. Res. 24, 471 (1990).CrossRefGoogle ScholarPubMed
8Salinas, A.J., Román, J., Vallet-Regi, M., Oliveira, J.M., Correia, R.N., and Fernande, M.H.: In vitro bioactivity of glass and glass-ceramics of the 3CaO·P2O5CaO·SiO2CaO·MgO·2SiO2 system. Biomaterials 21, 251 (2000).CrossRefGoogle ScholarPubMed
9Bosetti, M., Vernè, E., Ferraris, M., Ravaglioli, A., and Cannas, M.: In vitro characterization of zirconia coated by bioactive glass. Biomaterials 22, 987 (2001).CrossRefGoogle ScholarPubMed
10Hulshoff, J.E.G., van Dijk, K., van der Waerden, J.P.C.M., Wolke, J.G.C., Ginsel, L.A., and Jansen, J.A.: Biological evaluation of the effect of magnetron sputtered Ca/P coatings on osteoblast-like cells in vitro. J. Biomed. Mater. Res. 29, 967 (1995).CrossRefGoogle ScholarPubMed
11Liu, D.M., Chou, H.M., and Wu, J.D.: Plasma-sprayed hydroxyapatite coating–effect of different calcium-phosphate ceramics. J. Mater. Sci. Mater. Med. 5, 147 (1994).CrossRefGoogle Scholar
12Radin, S. and Ducheyne, P.: Plasma spraying induced changes of calcium phosphate ceramic characteristics and the effect on in vitro stability. J. Mater. Sci. Mater. Med. 3, 33 (1992).CrossRefGoogle Scholar
13Ektessabi, A.M.: Surface modification of biomedical implants using ion-beam-assisted sputter deposition. Nucl. Instrum. Meth. B 127, 1008 (1997).CrossRefGoogle Scholar
14Hamdi, M. and Ektessabi, A.M.: Electron beam deposition of thin bioceramics film for biomedical implant. Thin Solid Films 398, 385 (2001).CrossRefGoogle Scholar
15Kokubo, T., Kushitani, H., Sakka, S., Kitsugi, T., and Yamamuro, T.: Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J. Biomed. Mater. Res. 24, 721 (1990).CrossRefGoogle ScholarPubMed
16Hench, L.L.: Bioceramics—From concept to clinic. J. Am. Ceram. Soc. 74, 1487 (1991).CrossRefGoogle Scholar
17Rey, C., Collins, B., Goehl, T., Dickson, I.R., and Glimcher, M.J.: The carbonate environment in bone mineral: A resolution-enhanced Fourier transform infrared spectroscopy study. Calcif. Tissue Int. 45, 157 (1989).CrossRefGoogle ScholarPubMed
18Kim, C.Y., Clark, A.E., and Hench, L.L.: Early stages of calcium-phosphate layer formation in bioglasses. J. Non-Cryst. Solids 113, 195 (1989).CrossRefGoogle Scholar
19LeGeros, R.Z., Bonel, G., and Legros, R.: Types of “H2O” in human enamel and in precipitated apatites. Calcif. Tissue Res. 26, 111 (1978).CrossRefGoogle ScholarPubMed
20Arends, J., Christoffersen, J., Chistoffersen, M.R., Eckert, H., Fowler, B.O., Heughebaert, J.C., Nancollas, G.H., Yesinowski, J.P., and Zawacki, S.J.: A calcium hydroxyapatite precipitated from an aqueous-solution—An international multimethod analysis. J. Cryst. Growth 84, 515 (1987).CrossRefGoogle Scholar
21Kim, H.M., Kishimoto, K., Miyaji, F., Kokubo, T., Yao, T., Suetsugu, Y., Tanaka, J., and Nakamura, T.: Composition and structure of the apatite formed on PET substrates in SBF modified with various ionic activity products. J. Biomed. Mater. Res. 46, 228 (1999).3.0.CO;2-J>CrossRefGoogle ScholarPubMed
22Heughebaert, M., LeGeros, R.Z., Gineste, M., Guilhem, A., and Bonel, G.: Physicochemical characterization of deposits associated with HA ceramics implanted in nonosseous sites. J. Biomed. Mater. Res. 22, 257 (1988).CrossRefGoogle ScholarPubMed
23Zyman, Z., Weng, J., Liu, X., Li, X., and Zhang, X.: Phase and structural changes in hydroxyapatite coatings under heat treatment. Biomaterials 15, 151 (1994).CrossRefGoogle ScholarPubMed
24Ohtsuki, C., Kokubo, T., and Yamamuro, T.: Mechanism of apatite formation on CaO–SiO2–P2O5 glasses in a simulated body-fluid. J. Non-Cryst. Solids 143, 84 (1992).CrossRefGoogle Scholar
25Weng, J., Liu, Q., Wolke, J.G.C., Zhang, X., and de Groot, K.: Formation and characteristics of the apatite layer on plasma-sprayed hydroxyapatite coatings in simulated body fluid. Biomaterials 18, 1027 (1997).CrossRefGoogle ScholarPubMed