Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-28T00:05:46.308Z Has data issue: false hasContentIssue false
  • English
  • Français

Microwave-assisted solution combustion synthesis of high aspect ratio calcium phosphate nanoparticles

Published online by Cambridge University Press:  13 November 2013

Darcy E. Wagner ,
Joseph Lawrence  and
Sarit B. Bhaduri
Darcy E. Wagner*
Affiliation:
Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Toledo, Toledo, Ohio 43606
Joseph Lawrence
Affiliation:
Department of Bioengineering, College of Engineering, University of Toledo, Toledo, Ohio 43606
Sarit B. Bhaduri
Affiliation:
Department of Mechanical, Industrial, and Manufacturing Engineering, College of Engineering, University of Toledo, Toledo, Ohio 43606; and Division of Dentistry, College of Medicine, University of Toledo, Toledo, Ohio 43614
*
a)Address all correspondence to this author. e-mail: darcy.wagner@rockets.utoledo.edu
Get access

Abstract

Calcium phosphates (CaPs) are major chemical constituents of mammalian bone. Their osteoconductivity in vitro and in vivo has encouraged their use in biomaterial applications such as implant materials and drug delivery. High aspect ratio nanoparticles are attractive for many biomedical applications; however, precise control of the phase and morphology is challenging. The impact of fuel-to-oxidant ratio, pH, and cation chemistry on morphology and phase was studied for CaP-based compositions by microwave-assisted solution combustion synthesis (MASCS) in a urea–nitrate (fuel–oxidant) system. An initial calcium to phosphate ratio of 1.5 was used. Highly crystalline hydroxyapatite (HA) and biphasic CaP nanoparticle compositions were produced as confirmed by x-ray diffraction, scanning electron microscopy, and transmission electron microscopy. MASCS was capable of synthesizing high aspect ratio (∼5 to 20) single and biphasic CaP nanoparticles with diameters ranging from 250 to 500 nm and lengths between 2 and 10 μm.

Keywords

microwave heatingcombustion synthesisnanoscale
Type
Articles
Information
Journal of Materials Research , Volume 28 , Issue 22 , 28 November 2013 , pp. 3119 - 3129
Copyright
Copyright © Materials Research Society 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Wagner, D.E. and Bhaduri, S.B.: Progress and outlook of inorganic nanoparticles for delivery of nucleic acid sequences related to orthopedic pathologies: A review. Tissue Eng. Part B 18(1), 1 (2012).CrossRefGoogle ScholarPubMed
Dorozhkin, S. and Epple, M.: Biological and medical significance of calcium phosphates. Angew. Chem. Int. Ed. 41(17), 3130 (2002).3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Roy, I., Mitra, S., Maitra, A., and Mozumdar, S.: Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int. J. Pharm. 250(1), 25 (2003).CrossRefGoogle ScholarPubMed
Sokolova, V. and Epple, M.: Inorganic nanoparticles as carriers of nucleic acids into cells. Angew. Chem. Int. Ed. 47(8), 1382 (2008).CrossRefGoogle ScholarPubMed
Maitra, A.: Calcium phosphate nanoparticles: Second-generation nonviral vectors in gene therapy. Expert Rev. Mol. Diagn. 5(6), 893 (2005).CrossRefGoogle ScholarPubMed
Liu, J., Ye, X., Wang, H., Zhu, M., Wang, B., and Yan, H.: The influence of pH and temperature on the morphology of hydroxyapatite synthesized by hydrothermal method. Ceram. Int. 29(6), 629 (2003).CrossRefGoogle Scholar
Neira, I.S., Kolen'ko, Y.V., Lebedev, O.I., Van Tendeloo, G.V., Gupta, H.S., Guitan, F., and Yoshimura, M.: An effective morphology control of hydroxyapatite crystals via hydrothermal synthesis. Cryst. Growth Des. 9(1), 466 (2009).CrossRefGoogle Scholar
Neira, I.S., Guitian, F., Taniguchi, T., Watanabe, T., and Yoshimura, M.: Hydrothermal synthesis of hydroxyapatite whiskers with sharp faceted hexagonal morphology. J. Mater. Sci. 43(7), 2171 (2008).CrossRefGoogle Scholar
Varma, H.K., Kalkura, S.N., and Sivakumar, R.: Polymeric precursor route for the preparation of calcium phosphate compounds. Ceram. Int. 24(6), 467 (1998).CrossRefGoogle Scholar
Roeder, R.K., Converse, G.L., Leng, H., and Yue, W.: Kinetic effects on hydroxyapatite whiskers synthesized by the chelate decomposition method. J. Am. Ceram. Soc. 89(7), 2096 (2006).CrossRefGoogle Scholar
Zhang, H. and Darvell, B.W.: Morphology and structural characteristics of hydroxyapatite whiskers: Effect of the initial Ca concentration, Ca/P ratio and pH. Acta Biomater. 7(7), 2960 (2011).CrossRefGoogle ScholarPubMed
Wong, E.W., Sheehan, P.E., and Lieber, C.M.: Nanobeam mechanics: Elasticity, strength, and toughness of nanorods and nanotubes. Science 277(5334), 1971 (1997).CrossRefGoogle Scholar
Viswanath, B., Raghavan, R., Gurao, N.P., Ramamurty, U., and Ravishankar, N.: Mechanical properties of tricalcium phosphate single crystals grown by molten salt synthesis. Acta Biomater. 4(5), 1448 (2008).CrossRefGoogle ScholarPubMed
Rabinow, B.E.: Nanosuspensions in drug delivery. Nat. Rev. Drug Discovery 3(9), 785 (2004).CrossRefGoogle ScholarPubMed
Coelho, J.M., Agostinho Moreira, J., Almeida, A., and Monteiro, F.J.: Synthesis and characterization of HAp nanorods from a cationic surfactant template method. J. Mater. Sci. - Mater. Med. 21(9), 2543 (2010).CrossRefGoogle ScholarPubMed
Wang, A., Liu, D., Yin, H., Wu, H., Wada, Y., Ren, M., Jiang, T., Cheng, X., and Xu, Y.: Size-controlled synthesis of hydroxyapatite nanorods by chemical precipitation in the presence of organic modifiers. Mater. Sci. Eng., C 27(4), 865 (2007).CrossRefGoogle Scholar
Tas, A.C.: Combustion synthesis of calcium phosphate bioceramic powders. J. Eur. Ceram. Soc. 20(14–15), 2389 (2000).CrossRefGoogle Scholar
Vollmer, N. and Ayers, R.: Decomposition combustion synthesis of calcium phosphate powders for bone tissue engineering. Int. J. Self Propag. High Temp. Synth. 21(4), 189 (2012).CrossRefGoogle Scholar
Tas, A.C.: Molten salt synthesis of calcium hydroxyapatite whiskers. J. Am. Ceram. Soc. 84(2), 295 (2001).CrossRefGoogle Scholar
Mao, Y., Park, T-J., Zhang, F., Zhou, H., and Wong, S.S.: Environmentally friendly methodologies of nanostructure synthesis. Small 3(7), 1122 (2007).CrossRefGoogle ScholarPubMed
Cao, J.M., Feng, J., Deng, S.G., Chang, X., Wang, J., Liu, J.S., Lu, P., Lu, H.X., Zheng, M.B., Zhang, F., and Tao, J.: Microwave-assisted solid-state synthesis of hydroxyapatite nanorods at room temperature. J. Mater. Sci. 40(23), 6311 (2005).CrossRefGoogle Scholar
Liu, J., Li, K., Wang, H., Zhu, M., and Yan, H.: Rapid formation of hydroxyapatite nanostructures by microwave irradiation. Chem. Phys. Lett. 396(4–6), 429 (2004).CrossRefGoogle Scholar
Park, Y.M., Ryu, S.C., Yoon, S.Y., Stevens, R., and Park, H.C.: Preparation of whisker-shaped hydroxyapatite/β-tricalcium phosphate composite. Mater. Chem. Phys. 109(2–3), 440 (2008).CrossRefGoogle Scholar
Jalota, S., Tas, A.C., and Bhaduri, S.B.: Microwave-assisted synthesis of calcium phosphate nanowhiskers. J. Mater. Res. 19(6), 1876 (2004).CrossRefGoogle Scholar
Jain, S.R., Adiga, K.C., and Pai Verneker, V.R.: A new approach to thermochemical calculations of condensed fuel-oxidizer mixtures. Combust. Flame 40(0), 71 (1981).CrossRefGoogle Scholar
García-Tuñón, E., Couceiro, R., Franco, J., Saiz, E., and Guitián, F.: Synthesis and characterisation of large chlorapatite single-crystals with controlled morphology and surface roughness. J. Mater. Sci. - Mater. Med. 23(10), 2471 (2012).CrossRefGoogle ScholarPubMed
Son, S.J., Bai, X., and Lee, S.B.: Inorganic hollow nanoparticles and nanotubes in nanomedicine: Part 1. Drug/gene delivery applications. Drug Discovery Today 12(15–16), 650 (2007).CrossRefGoogle ScholarPubMed
Son, S.J., Bai, X., and Lee, S.B.: Inorganic hollow nanoparticles and nanotubes in nanomedicine: Part 2: Imaging, diagnostic, and therapeutic applications. Drug Discovery Today 12(15–16), 657 (2007).CrossRefGoogle ScholarPubMed
Burgos-Montes, O., Moreno, R., Colomer, M.T., and Fariñas, J.C.: Synthesis of mullite powders through a suspension combustion process. J. Am. Ceram. Soc. 89(2), 484 (2006).CrossRefGoogle Scholar
Chowdhury, E.H., Kunou, M., Nagaoka, M., Kundu, A.K., Hoshiba, T., and Akaike, T.: High-efficiency gene delivery for expression in mammalian cells by nanoprecipitates of Ca–Mg phosphate. Gene 341, 77 (2004).CrossRefGoogle ScholarPubMed
Zhou, H., Luchini, T.F., and Bhaduri, S.: Microwave assisted synthesis of amorphous magnesium phosphate nanospheres. J. Mater. Sci. - Mater. Med. 23(12), 2831 (2012).CrossRefGoogle ScholarPubMed