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Optical biosensors utilizing graphene and functional DNA molecules

Published online by Cambridge University Press:  03 April 2017

Sepehr Manochehry ,
Meng Liu ,
Dingran Chang  and
Yingfu Li
Sepehr Manochehry
Affiliation:
Department of Biochemistry and Biomedical Sciences, Health Science Centre, McMaster University, Hamilton, Ontario L8S 4K1
Meng Liu
Affiliation:
Department of Biochemistry and Biomedical Sciences, Health Science Centre, McMaster University, Hamilton, Ontario L8S 4K1
Dingran Chang
Affiliation:
Department of Biochemistry and Biomedical Sciences, Health Science Centre, McMaster University, Hamilton, Ontario L8S 4K1
Yingfu Li*
Affiliation:
Department of Biochemistry and Biomedical Sciences, Health Science Centre, McMaster University, Hamilton, Ontario L8S 4K1
*
a) Address all correspondence to this author. e-mail: liying@mcmaster.ca
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Abstract

Single-stranded DNA molecules capable of molecular recognition and catalysis can now be routinely generated via the technique of in vitro selection. When coupled with adequate signal transduction modes, these synthetic functional DNA species represent a potential paradigm shift in the research and development of biosensors to meet the challenges of our rapidly changing world. Coupling functional DNA molecules with graphene materials for the design of optical biosensors has become an exciting research area in recent years, mostly because graphene materials are not only excellent quenchers of fluorescence, but they also display considerably different affinities for free and ligand-bound functional DNA molecules. We will discuss notable progress in this area in this mini-review by highlighting representative studies.

Keywords

opticalsensorbiomaterial
Type
Invited Articles
Information
Journal of Materials Research , Volume 32 , Issue 15: Focus Issue: Two-Dimensional Nanomaterials for Biosensors , 14 August 2017 , pp. 2973 - 2983
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Copyright
Copyright © Materials Research Society 2017 

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Footnotes

Contributing Editor: Venkatesan Renugopalakrishnan

References

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