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Synthesis of nanosized calcium hydroxyapatite particles by the catalytic decomposition of urea with urease

Published online by Cambridge University Press:  03 March 2011

Bojan Jokic ,
Dusanka Tanaskovic ,
Ivona Jankovic-Castvan ,
Sasa Drmanic ,
Rada Petrovic  and
Djordje Janackovic
Bojan Jokic
Affiliation:
Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
Dusanka Tanaskovic
Affiliation:
Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
Ivona Jankovic-Castvan
Affiliation:
Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
Sasa Drmanic
Affiliation:
Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
Rada Petrovic
Affiliation:
Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
Djordje Janackovic*
Affiliation:
Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
*
a) Address all correspondence to this author. e-mail: nht@tmf.bg.ac.yu
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Abstract

Nanosized calcium hydroxyapatite particles were synthesized by the catalytic decomposition of urea with urease. The influence of the synthesis parameters, i.e., temperature and ratio of the reagents/urease concentrations, on the size and morphology of the hydroxyapatite particles were investigated. As reagents for the synthesis of hydroxyapatite, various amounts of CaCl2, NaH2PO4, urea, and urease were used. The urease-catalyzed decomposition of urea leads to the homogeneous precipitation of hydroxyapatite because of the release of OH− ions during the hydrolysis of urea. In the same process, CO32− ions are also released and incorporated into the crystal structure of the hydroxyapatite. In the temperature range from 30–40 °C, it was found that low crystalline carbonate hydroxyapatite was formed in all cases. It was found that decreasing the ratio of the concentrations of the reagents to the urease concentration leads to decrease in the particle size to below 100 nm and the morphology changes from leafy-like to spherical.

Keywords

MorphologyNanoscalePowder processing
Type
Articles
Information
Journal of Materials Research , Volume 22 , Issue 5 , May 2007 , pp. 1156 - 1161
Copyright
Copyright © Materials Research Society 2007

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