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Adhesion and interfacial fracture in drug-eluting stents

Published online by Cambridge University Press:  31 January 2011

Juan Meng ,
Argjenta Orana ,
Ting Tan ,
Kurt Wolf ,
Nima Rahbar ,
Hannah Li ,
George Papandreou ,
Cynthia Maryanoff  and
Wole Soboyejo
Juan Meng
Affiliation:
Princeton Institute of Science and Technology of Materials, and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544
Argjenta Orana
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania 19446
Ting Tan
Affiliation:
Princeton Institute of Science and Technology of Materials, and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544
Kurt Wolf
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania 19446
Nima Rahbar
Affiliation:
Department of Civil and Environmental Engineering, University of Massachusetts–Dartmouth, North Dartmouth, Massachusetts 02747
George Papandreou
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Warren, New Jersey 07059
Cynthia Maryanoff
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania 19446
Wole Soboyejo*
Affiliation:
Princeton Institute of Science and Technology of Materials, and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544
*
a)Address all correspondence to this author. e-mail: soboyejo@princeton.edu
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Abstract

This paper presents experimental and theoretical studies of the adhesion between the drug-eluting layer and a Parylene C primer layer in coatings present on a model drug-eluting stent. To quantify adhesion, Brazil nut sandwich specimens were prepared mimicking the layers of this coating. These samples were stressed to fracture, and the resulting initial cracks at the Parylene C/drug interface were used to measure the dependence of interfacial fracture energy of mode mixity. The mating fracture surfaces were then analyzed using scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDX). The interfacial energy release rates were obtained over a wide variety of mode mixities. Adhesion and fracture mechanics models were then used to estimate the mode mixity dependency of interfacial fracture toughness. Fracture toughness was found to be larger under higher mode mixity than that under lower mixity and the analytical model showed close agreement with experimental results.

Keywords

AdhesionFractureCoating
Type
Articles
Information
Journal of Materials Research , Volume 25 , Issue 4 , April 2010 , pp. 641 - 647
Copyright
Copyright © Materials Research Society 2010

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References

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