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Controlled loading of paramagnetic gadolinium oxide nanoplates in PMAO-g-PEG as effective T1-weighted MRI contrast agents

Published online by Cambridge University Press:  07 August 2014

Jiaquan Yuan ,
Erwin Peng  and
Jun Min Xue
Jiaquan Yuan
Affiliation:
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore (NUS), Singapore 117574, Singapore
Erwin Peng
Affiliation:
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore (NUS), Singapore 117574, Singapore
Jun Min Xue*
Affiliation:
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore (NUS), Singapore 117574, Singapore
*
a)Address all correspondence to this author. e-mail: msexuejm@nus.edu.sg
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Abstract

Plate-shaped Gd2O3 nanoclusters (GNCs) with well-controlled loading were fabricated by using amphiphilic poly(maleic anhydride-alt-1-octadecene) (PMAO) grafted with PEG as nanogel. The hydrodynamic size of the obtained GNCs was well controlled to <260 nm under appropriate emulsion process conditions and they showed excellent long-term dispersibility in phosphate buffer saline. MRI measurements clearly indicated the substantial improvement in T1 effect of the nanoclusters as compared with the individual Gd2O3 nanoplates. The obtained GNCs possessed a high r1 value of 7.948 s−1mM−1 [Gd], which is 2.23 times higher than that of the commercial product Gd-DOTA, and low r2/r1 of 1.04. In vitro test of the obtained GNCs was demonstrated in NIH/3T3 cell lines, and clear T1-weighted images were obtained. Thus, the PMAO-g-PEG assisted GNCs were potentially useful for T1-weighted MRI contrast agents.

Keywords

nanostructurecluster assemblybiomedical
Type
Articles
Information
Journal of Materials Research , Volume 29 , Issue 15 , 14 August 2014 , pp. 1626 - 1634
Copyright
Copyright © Materials Research Society 2014 

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