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Effect of charge density on water sorption and elasticity of stimuli-responsive poly(acrylamide–itaconic acid) and poly(N,N-dimethylacrylamide–itaconic acid) hydrogels: Comparison of experiment with theory

Published online by Cambridge University Press:  25 November 2013

Tayyibe Celik  and
Nermin Orakdogen
Tayyibe Celik
Affiliation:
Department of Chemistry, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey
Nermin Orakdogen*
Affiliation:
Department of Chemistry, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey
*
a)Address all correspondence to this author. e-mail: orakdogen@itu.edu.tr
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Abstract

In this study, stimuli-responsive ionic poly(acrylamide–itaconic acid) (P(AAm–IA)) and poly(N,N-dimethylacrylamide–itaconic acid) (P(DMA–IA)) hydrogels have been prepared by free radical crosslinking copolymerization in aqueous solution using N,N-methylenebisacrylamide as the crosslinking agent. In particular, the swelling ratio and elasticity of both hydrogel systems including the effect of ionic comonomer itaconic acid (IA) content were investigated. In spite of the similarity in monomer/crosslinker ratio and the content of ionic comonomer in the hydrogel structures, comparable differences were observed in their swelling capacity and elasticity. Compared to P(DMA–IA) hydrogels, P(AAm–IA) hydrogels exhibit higher swelling capacity in water and a more pronounced dependency of the swelling ratio on the ionic comonomer content. The incorporation of a small amount of IA into the network structure causes the hydrogel system to exhibit polyelectrolyte type swelling behavior. P(AAm–IA) and P(DMA–IA) hydrogels showed good response to the valency of counterions and pH of the external solution.

Type
Articles
Information
Journal of Materials Research , Volume 28 , Issue 23 , 14 December 2013 , pp. 3234 - 3244
Copyright
Copyright © Materials Research Society 2013 

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References

REFERENCES

Samchenko, Y., Ulberg, Z., and Korotych, O.: Multipurpose smart hydrogel systems. Adv. Colloid Interface Sci. 168, 247–262 (2011).Google Scholar
Peppas, N.A., Bures, P., Leobandung, W., and Ichikawa, H.: Hydrogels in pharmaceutical formulations. Eur. J. Pharm. Biopharm. 50, 27–46 (2000).Google Scholar
Qui, Y. and Park, K.: Environment-sensitive hydrogels for drug delivery. Adv. Drug Delivery Rev. 53, 321–339 (2001).Google Scholar
Gil, E.S. and Hudson, S.M.: Stimuli-responsive polymers and their bioconjugates. Prog. Polym. Sci. 29, 1173–1222 (2004).Google Scholar
Eeckman, F., Moes, A.J., and Amighi, K.: Synthesis and characterization of thermosensitive copolymers for oral controlled drug delivery. Eur. Polym. J. 40, 873–881 (2004).CrossRefGoogle Scholar
Kopecek, J., Sprincl, L., Bazilova, H., and Vacik, J.: Biological tolerance of poly(N-substituted acrylamides). J. Biomed. Mater. Res. 7, 111 (1973).Google Scholar
Gupta, P., Vermani, K., and Garg, S.: Hydrogels: From controlled release to pH-responsive drug delivery. Drug Delivery Today 7, 569–578 (2002).Google Scholar
Çaykara, T., Dogmus, M., and Kantoglu, O.: Network structure and swelling-shrinking behaviour of pH-sensitive poly(acrylamide-co-itaconic acid) hydrogels. J. Polym. Sci., Part B: Polym. Phys. 42, 2586–2594 (2004).CrossRefGoogle Scholar
Rodriguez, E. and Katime, I.: Behavior of acrylic acid-itaconic acid hydrogels in swelling, shrinking, and uptakes of some metal ions from aqueous solution. J. Appl. Polym. Sci. 90, 530–536 (2003).Google Scholar
Hwang, J.S., Yuk, K.Y., and Huh, K.M.: Research and development of superporous hydrogels with fast swelling and superabsorbent properties. Tissue Eng. Regen. Med. 5(2), 147–155 (2008).Google Scholar
Tomic, S.L., Mićić, M.M., Dobic, S.N., Filipovic, J.M., and Suljovrujic, E.H.: Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. Radiat. Phys. Chem. 79, 643–649 (2010).Google Scholar
Krušić, M.K. and Filipovic, J.: Copolymer hydrogels based on N-isopropylacrylamide and itaconic acid. Polymer 47, 148–155 (2006).CrossRefGoogle Scholar
El-Neser, E.M.: Effect of chemical structure on the properties of some hydrogels prepared by using gamma radiation polymerization. Polym. Adv. Technol. 16, 489–494 (2005).Google Scholar
Bajpai, S.K. and Sonkusley, J.: Hydrogels for oral drug delivery of peptides: Synthesis and characterization. J. Appl. Polym. Sci. 83, 1717–1729 (2002).Google Scholar
Flory, P.J. and Rehner, J.: Statistical mechanics of cross-linked polymer networks II. Swelling. J. Chem. Phys. 11, 521–526 (1943).CrossRefGoogle Scholar
Orakdogen, N.: pH-responsive swelling behavior, elasticity and molecular characteristics of poly(N,N-dimethylaminoethyl methacrylate) gels at various initial monomer concentrations. Polym. Bull. 67, 1347–1366 (2011).Google Scholar
Treloar, L.R.G.: The Physics of Rubber Elasticity (University Press, Oxford, 1975).Google Scholar
James, H.M. and Guth, E.: Theory of the elastic properties of rubber. J. Chem. Phys. 11, 455–481 (1943).Google Scholar
Naghash, H.J., Massah, A., and Erfan, A.: Free-radical crosslinking copolymerization of acrylamide and N,N′-methylenebis acrylamide by used Ce(IV)/polyethylene glycol and Ce(IV)/diethylmalonate redox initiator systems. Eur. Polym. J. 38, 147–150 (2002).Google Scholar
Orakdogen, N. and Okay, O.: Correlation between crosslinking efficiency and spatial inhomogeneity in poly(acrylamide) hydrogels. Polym. Bull. 57, 631–641 (2006).Google Scholar
Sen, M. and Guven, O.: Dynamic deswelling studies of poly(N-vinyl-2-pyrrolidone/itaconic acid) hydrogels swollen in water and terbinafine hydrochloride solutions. Eur. Polym. J. 38, 751–757 (2002).Google Scholar
Kurenkov, V.F., Hartan, H.G., and Lobanov, F.I.: Alkaline hydrolysis of polyacrylamide. Russ. J. Appl. Chem. 74, 543–554 (2001).CrossRefGoogle Scholar
Kudryavtsev, Y.V., Litmanovich, A.D., and Plate, N.A.: On the kinetics of polyacrylamide alkaline hydrolysis. Macromolecules 31(4), 4642–4644 (1998).Google Scholar
Kizilay, M. and Okay, O.: Effect of hydrolysis on spatial inhomogeneity in poly(acrylamide) gels of various crosslink densities. Polymer 44, 5239–5250 (2003).Google Scholar
Okay, O. and Durmaz, S.: Charge density dependence of elastic modulus of strong polyelectrolyte hydrogels. Polymer 43, 1215–1221 (2002).Google Scholar
Flory, P.J.: Principle of Polymer Chemistry (Cornell University Press, Ithaca, New York, 1953).Google Scholar
Huggins, M.L.: Some properties of solutions of long-chain compounds. J. Chem. Phys. 46, 151–158 (1942).Google Scholar
Gundogan, N., Melekaslan, D., and Okay, O.: Rubber elasticity of poly(N-isopropylacrylamide) gels at various charge densities. Macromolecules 35, 5616–5622 (2002).Google Scholar
Gundogan, N., Melekaslan, D., and Okay, O.: Non-Gaussian elasticity of swollen poly(N-isopropylacrylamide) gels at high charge densities. Eur. Polym. J. 39, 2209–2216 (2003).Google Scholar