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Evaluation of Ti implants coated with Ag-containing borate bioactive glass for simultaneous eradication of infection and fracture fixation in a rabbit tibial model

Published online by Cambridge University Press:  05 December 2012

Wei Xiao ,
Shi-Hua Luo ,
Xiao-Juan Wei ,
Chang-Qing Zhang ,
Wen-Hai Huang ,
Jia-Kang Chen ,
Yong Cai ,
Yong Rui  and
Mohamed N. Rahaman
Wei Xiao
Affiliation:
Department of Materials Science and Engineering, Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China
Shi-Hua Luo
Affiliation:
Department of Traumatology, Shanghai Ruijin Hospital, Jiaotong University, Shanghai 200025, China
Xiao-Juan Wei
Affiliation:
Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital, Jiaotong University, Shanghai 200233, China
Chang-Qing Zhang
Affiliation:
Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital, Jiaotong University, Shanghai 200233, China
Wen-Hai Huang*
Affiliation:
Department of Materials Science and Engineering, Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China
Jia-Kang Chen
Affiliation:
Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China
Yong Cai
Affiliation:
Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China
Yong Rui
Affiliation:
Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China
Mohamed N. Rahaman
Affiliation:
Department of Materials Science and Engineering, Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Missouri 65409-0340
*
a)Address all correspondence to this author. e-mail: huangwe@mst.edu
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Abstract

The ability of silver (Ag)-containing borate bioactive glass (BG) coatings to improve the biocompatibility and antibacterial properties of titanium (Ti) implants was investigated in vitro and in vivo in a rabbit tibial fracture model. Dense coatings of borate BG (thickness ≈ 20 μm) containing 0, 0.75, and 1.0 wt% Ag2O were prepared by depositing a layer of particles on Ti plates, followed by sintering at 900 °C. The as-prepared coatings had an adhesive strength of 10 ± 1 MPa, and when immersed in an aqueous phosphate (K2HPO4) solution, the coatings converted to hydroxyapatite, releasing Ag+ ions continuously for over 4 wk. After implantation of BG-coated Ti constructs in a rabbit tibial fracture model and of methicillin-resistant Staphylococcus aureus-induced osteomyelitis, the BG coating doped with 1.0 wt% Ag2O was most effective for the simultaneous eradication of the infection and fracture fixation. Implants coated with Ag-containing BG coatings could provide an approach for reducing implant-related bone infection.

Keywords

silver-containing borate glassbacteriostasisbioactive glass coatingbone infectionbone fracture repair
Type
Articles
Information
Journal of Materials Research , Volume 27 , Issue 24 , 28 December 2012 , pp. 3147 - 3156
Copyright
Copyright © Materials Research Society 2012

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