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Evaluation of Ti implants coated with Ag-containing borate bioactive glass for simultaneous eradication of infection and fracture fixation in a rabbit tibial model

Published online by Cambridge University Press:  05 December 2012

Wei Xiao ,
Shi-Hua Luo ,
Xiao-Juan Wei ,
Chang-Qing Zhang ,
Wen-Hai Huang ,
Jia-Kang Chen ,
Yong Cai ,
Yong Rui  and
Mohamed N. Rahaman
Wei Xiao
Affiliation:
Department of Materials Science and Engineering, Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China
Shi-Hua Luo
Affiliation:
Department of Traumatology, Shanghai Ruijin Hospital, Jiaotong University, Shanghai 200025, China
Xiao-Juan Wei
Affiliation:
Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital, Jiaotong University, Shanghai 200233, China
Chang-Qing Zhang
Affiliation:
Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital, Jiaotong University, Shanghai 200233, China
Wen-Hai Huang*
Affiliation:
Department of Materials Science and Engineering, Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China
Jia-Kang Chen
Affiliation:
Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China
Yong Cai
Affiliation:
Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China
Yong Rui
Affiliation:
Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China
Mohamed N. Rahaman
Affiliation:
Department of Materials Science and Engineering, Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Missouri 65409-0340
*
a)Address all correspondence to this author. e-mail: huangwe@mst.edu
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Abstract

The ability of silver (Ag)-containing borate bioactive glass (BG) coatings to improve the biocompatibility and antibacterial properties of titanium (Ti) implants was investigated in vitro and in vivo in a rabbit tibial fracture model. Dense coatings of borate BG (thickness ≈ 20 μm) containing 0, 0.75, and 1.0 wt% Ag2O were prepared by depositing a layer of particles on Ti plates, followed by sintering at 900 °C. The as-prepared coatings had an adhesive strength of 10 ± 1 MPa, and when immersed in an aqueous phosphate (K2HPO4) solution, the coatings converted to hydroxyapatite, releasing Ag+ ions continuously for over 4 wk. After implantation of BG-coated Ti constructs in a rabbit tibial fracture model and of methicillin-resistant Staphylococcus aureus-induced osteomyelitis, the BG coating doped with 1.0 wt% Ag2O was most effective for the simultaneous eradication of the infection and fracture fixation. Implants coated with Ag-containing BG coatings could provide an approach for reducing implant-related bone infection.

Keywords

silver-containing borate glassbacteriostasisbioactive glass coatingbone infectionbone fracture repair
Type
Articles
Information
Journal of Materials Research , Volume 27 , Issue 24 , 28 December 2012 , pp. 3147 - 3156
Copyright
Copyright © Materials Research Society 2012

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References

REFERENCES

Hench, L.L., Splinter, R.J., Allen, W.C., and Greenlee, T.K. Jr.: Bonding mechanisms at the interface of ceramic prosthetic materials. J. Biomed. Mater. Res. 5, 117–141 (1971).CrossRefGoogle Scholar
Hench, L.L.: Bioceramics. J. Am. Ceram. Soc. 81, 1705–1728 (1998).CrossRefGoogle Scholar
Hench, L.L. and Andersson, O.: Bioactive glasses, in An Introduction to Bioceramics, Hench, L.L. and Wilson, J., eds. (World Scientific, Singapore, 1993); pp. 41–62.CrossRefGoogle Scholar
Alta, V., Bechert, T., Steinrucke, P., Wagener, M., and Seidel, P.: An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. Biomaterials 25, 4384–4391 (2004).Google Scholar
Esposito, M., Hirsch, J.M., Lekholm, U., and Thomsen, P.: Biological factors contributing to failures of osseointegrated oral implants. II. Etiopathogenesis. Eur. J. Oral Sci. 106, 721–764 (1998).CrossRefGoogle ScholarPubMed
Costerton, J.W., Ellis, B., Lam, K., Johnson, F., and Khoury, A.E.: Mechanism of electrical enhancement of efficacy of antibiotics in killing biofilm. Antimicrob. Agents Chemother. 38, 397–404 (1994).CrossRefGoogle ScholarPubMed
Schierholz, J.M., Morsczeck, C., Brenner, N., Konig, D.P., Yucel, N., and Korenkov, M.: Special aspects of implant-associated infection in orthopedic surgery. Orthopade 33, 397–404 (2004).CrossRefGoogle ScholarPubMed
Eggimann, P. and Pittet, D.: Infection control in the ICU. Chest 120, 2059–2093 (2001).CrossRefGoogle ScholarPubMed
Harbarth, S., Samore, M.H., Lichtenberg, D., and Carmeli, Y.: Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation 101, 2916–2921 (2000).CrossRefGoogle ScholarPubMed
Hench, L.L. and Andersson, O.: Bioactive glass coatings, in An Introduction to Bioceramics, Hench, L.L. and Wilson, J., eds. (World Scientific, Singapore, 1993); pp. 239–260.CrossRefGoogle Scholar
Hench, L.L. and Greenspan, D.C.: Bioglass coated Al2O3 ceramics. U.S. Patent 4,103,002, July 25, 1978.Google Scholar
Ducheyne, P.: Bioglass coating and bioglass composites as implant materials. J. Biomed. Mater. Res. 19, 273–291 (1985).CrossRefGoogle ScholarPubMed
Gabbi, G., Cacchioli, A., Locardi, B., and Guadagnino, E.: Bioactive glass coating: Physicochemical aspects and biological findings. Biomaterials 16, 515–520 (1995).CrossRefGoogle ScholarPubMed
Pazo, A., Saiz, E., and Tomsia, A.P.: Silicate glass coatings on Ti-based implants. Acta Mater. 46, 2551–2558 (1998).CrossRefGoogle Scholar
Gomez-Vega, J.M., Saiz, E., and Tomsia, A.P.: Glass-based coating for titanium implant alloys. J. Biomed. Mater. Res. 46, 549–559 (1999).3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Bosetti, M., Verne, E., Ferraris, M., Ravaglioli, A., and Cannas, M.: In vitro characterization of zirconia coated by bioactive glass. Biomaterials 22, 987–994 (2001).CrossRefGoogle ScholarPubMed
Kim, H.W., George, G., Knowles, J.C., Koh, Y.H., and Kim, H.E.: Calcium phosphates and glass composite coatings on zirconia for enhanced biocompatibility. Biomaterials 25, 4203–4213 (2004).CrossRefGoogle ScholarPubMed
Peddi, L., Brow, R.K., and Brown, R.F.: Bioactive borate glass coatings titanium alloys. J. Mater. Sci. - Mater. Med. 19, 3145–3152 (2008).CrossRefGoogle ScholarPubMed
Rahaman, M.N., Li, Y., Bal, B.S., and Huang, W.: Functionally graded bioactive glass coatings on magnesia partially stabilized zirconia for enhanced biocompatibility. J. Mater. Sci. - Mater. Med. 19, 2325–2333 (2008).CrossRefGoogle ScholarPubMed
Liang, W., Rahaman, M.N., Day, D.E., Marion, N.W., Riley, G.C., and Mao, J.J.: Bioactive borate glass scaffold for bone tissue engineering. J. Non-Cryst. Solids 354, 1690–1696 (2008).CrossRefGoogle Scholar
Huang, W.H., Day, D.E., Kittiratanapiboon, K., and Rahaman, M.N.: Kinetics and mechanism of the conversion of silicate (45S5), borate and borosilicate glasses to hydroxyapatite in dilute phosphate solutions. J. Mater. Sci. - Mater. Med. 17, 583–596 (2006).CrossRefGoogle ScholarPubMed
Day, D.E., White, J.E., Brown, R.F., and McMenamin, K.D.: Transformation of borate glasses into biologically useful materials. Glass Technol. 44, 75–81 (2003).Google Scholar
Han, X. and Day, E.D.: Reaction of sodium calcium borate glasses to form hydroxyapatite. J. Mater. Sci. - Mater. Med. 18, 1837–1847 (2007).CrossRefGoogle ScholarPubMed
Lopez-Esteban, S., Saiz, E., Fujino, S., Oku, T., Suganuma, K., and Tomsia, A.P.: Bioactive glass coatings for orthopedic metallic implants. J. Eur. Ceram. Soc. 23, 2912–2930 (2003).CrossRefGoogle Scholar
Fu, Q., Rahaman, M.N., Bal, B.S., Kuroki, K., and Brown, R.F.: Bioactive glass scaffolds with controllable degradation rates for bone tissue engineering applications, II: In vitro and in vivo biological evaluation. J. Biomed. Mater. Res. Part A 95, 172–179 (2010).CrossRefGoogle Scholar
Pan, H.B., Zhao, X.L., Zhang, X., Zhang, K.B., Li, L.C., Li, Z.Y., Lam, W.M., Lu, W.W., Wang, D.P., Huang, W.H., Lin, K.L., and Chang, J.: Strontium-borate glass: Potential biomaterial for bone regeneration. J. R. Soc. Interface 7, 1025–1031 (2010).CrossRefGoogle ScholarPubMed
Adams, A.P., Santchi, E.M., and Millencamp, M.A.: Antibacterial properties of silver chloride coated nylon wound dressing. Vet. Surg. 28, 219–225(1999).CrossRefGoogle ScholarPubMed
Yorganci, K., Krepel, C., Weiget, J.A., and Edmiston, C.E.: In vitro evaluation of the antibacterial activity of three different central venous catheters against gram-positive bacteria. Eur. J. Clin. Microbiol. Infect. Dis. 21, 379–384 (2002).Google ScholarPubMed
Silver, S.: Bacterial silver resistance: Molecular biology and uses and misuses of silver compounds. FEMS Microbiol. Rev. 27, 341–353 (2003).CrossRefGoogle ScholarPubMed
Luo, S.H., Xiao, W., Wei, X.J., Jia, W.T., Zhang, C.Q., Huang, W.H., Jin, D.X., Rahaman, M.N., and Day, D.E.: In vitro evaluation of cytotoxicity of silver-containing borate bioactive glass. J. Biomed. Mater. Res. Part B 95, 441–448 (2010).CrossRefGoogle ScholarPubMed
Morgan, E.F., Mason, Z.D., Chien, K.B., Pfeiffer, A.J., Barnes, G.L., Einhorn, T.A., and Gerstenfeld, L.C.: Micro-computed tomography assessment of fracture healing: Relationships among callus structure, composition, and mechanical function. Bone 44, 335–344 (2009).CrossRefGoogle ScholarPubMed
Nyman, J.S., Munoz, S., Jadhav, S., Mansour, A., Yoshii, T., Mundy, G.R., and Gutierrez, G.E.: Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography. J. Biomech. 42, 891–897 (2009).CrossRefGoogle ScholarPubMed
Gu, Y.F., Xiao, W., Lu, L.N., Huang, W.H., Rahaman, M.N., and Wang, D.P.: Kinetics and mechanisms of converting bioactive glasses to hydroxyapatite in aqueous phosphate solution. J. Mater. Sci. 46, 47–54 (2011).CrossRefGoogle Scholar
Walenkamp, G.H.I.M.: Gentamicin PMMA beads. A clinical pharmacokinetic and toxicological study. Thesis, University of Nijmegen, The Netherlands, 1983.Google Scholar
Kumar, R. and Munstedt, H.: Silver ion release from antimicrobial polyamide/silver composites. Biomaterials 26, 2081–2088 (2005).CrossRefGoogle ScholarPubMed
Huang, W.H., Rahaman, M.N., Day, D.E., and Li, Y.: Mechanisms for converting bioactive silicate, borate and borosilicate glasses to hydroxyapatite in dilute phosphate solutions. Phys. Chem. Glasses Part B 47, 647–658 (2006).Google Scholar
McCoy, H., Kenney, M.A., Montgomery, C., Irwin, A., Williams, L., and Orrell, R.: Relation of boron to the composition and mechanical properties of bone. Environ. Health Prospect. 102, 49–53 (1994).Google Scholar
Ning, J., Yao, A.H., Wang, D.P., Huang, W.H., Fu, H.L., Liu, X., Jiang, X.Q., and Zhang, X.L.: Synthesis and in vitro bioactivity of a borate-based bioglass. Mater. Lett. 61, 5223–5226 (2007).CrossRefGoogle Scholar