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Improved performance of the functionalized nitinol as a prospective bone implant material

Published online by Cambridge University Press:  19 July 2018

Sarmita Sinha ,
Howa Begam ,
Vinod Kumar ,
Samit Kumar Nandi ,
Jerzy Kubacki  and
Abhijit Chanda
Sarmita Sinha
Affiliation:
Department of Mechanical Engineering, Jadavpur University, Kolkata-700032, India
Howa Begam
Affiliation:
School of Bioscience and Engineering, Jadavpur University, Kolkata-700032, India
Vinod Kumar
Affiliation:
Department of Veterinary Surgery & Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata-700037, India
Samit Kumar Nandi*
Affiliation:
Department of Veterinary Surgery & Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata-700037, India
Jerzy Kubacki*
Affiliation:
A. Chełkowski Institute of Physics, University of Silesia, Katowice 40-007, Poland
Abhijit Chanda*
Affiliation:
Department of Mechanical Engineering, Jadavpur University, Kolkata-700032, India
*
a)Address all correspondence to these authors. e-mail: samitnandi1967@gmail.com
b)e-mail: abhijitchanda.biomed@gmail.com
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Abstract

Nitinol, being a shape memory and super elastic alloy, is used in medical industry. Surface modification of nitinol helps to reduce the nickel ion leaching in physiological environment. The purpose of this study is to modify the nitinol surface by the silanization technique and to conduct a comparative investigation with the bare nitinol in the aspect of leaching of nickel ion, hemocompatibility, and in vivo animal response. X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy studies confirmed the addition of organofunctional alkoxysilane molecules through the silanization process. The histological study showed the presence of adequate number of osteoblasts in silanized nitinol. The fluorochrome labeling study depicted more new bone formation (8 and 21% higher) in silanized nitinol specimens than bare one at one and three months postoperatively. Radiology and SEM study also proved the better performance of silanized samples. The cumulative in vivo results indicate its suitability as the potential bioimplant in various orthopedic surgical uses.

Keywords

nitinolsilanisationin vivo
Type
Article
Information
Journal of Materials Research , Volume 33 , Issue 17 , 14 September 2018 , pp. 2554 - 2564
Copyright
Copyright © Materials Research Society 2018 

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