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Magnetoresistive sensors and magnetic nanoparticles for biotechnology

Published online by Cambridge University Press:  01 December 2005

Guenter Reiss ,
Hubert Brueckl ,
Andreas Huetten ,
Joerg Schotter ,
Monika Brzeska ,
Michael Panhorst ,
Daniela Sudfeld ,
Anke Becker ,
Paul B. Kamp  and
Alfred Puehler
...Show all authors
Guenter Reiss*
Affiliation:
Department of Physics, University of Bielefeld, 33501 Bielefeld, Germany
Hubert Brueckl
Affiliation:
Department of Physics, University of Bielefeld, 33501 Bielefeld, Germany
Andreas Huetten
Affiliation:
Department of Physics, University of Bielefeld, 33501 Bielefeld, Germany
Joerg Schotter
Affiliation:
Department of Physics, University of Bielefeld, 33501 Bielefeld, Germany
Monika Brzeska
Affiliation:
Department of Physics, University of Bielefeld, 33501 Bielefeld, Germany
Michael Panhorst
Affiliation:
Department of Physics, University of Bielefeld, 33501 Bielefeld, Germany
Daniela Sudfeld
Affiliation:
Department of Physics, University of Bielefeld, 33501 Bielefeld, Germany
Anke Becker
Affiliation:
Department of Biology, University of Bielefeld, 33501 Bielefeld, Germany
Paul B. Kamp
Affiliation:
Department of Biology, University of Bielefeld, 33501 Bielefeld, Germany
Alfred Puehler
Affiliation:
Department of Biology, University of Bielefeld, 33501 Bielefeld, Germany
Klaus Wojczykowski
Affiliation:
Department of Chemistry, University of Bielefeld, 33501 Bielefeld, Germany
Peter Jutzi
Affiliation:
Department of Chemistry, University of Bielefeld, 33501 Bielefeld, Germany
*
a)Address all correspondence to this author. e-mail: reiss@physik.uni-bielefeld.de This paper was selected as the Outstanding Meeting Paper for the 2004 MRS Fall Meeting Symposium I Proceedings, Vol. 853E.
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Abstract

Magnetoresistive biosensors use a new detection method for molecular recognition reactions based on two recently developed techniques and devices: Magnetic markers and XMR sensors, where XMR means either giant magnetoresistance (GMR) or tunneling magnetoresistance (TMR). The markers are specifically attached to the target molecules, and their magnetic stray field is picked up by an embedded magnetoresistive sensor as a change of the electrical resistance. Compared to established, e.g., fluorescent, detection methods, magnetic biosensors have a number of advantages, including low molecular detection limits, flexibility, and the direct availability of an electronic signal suitable for further automated analysis. This makes them a promising choice for the detection units of future widespread and easy-to-use lab-on-a-chip systems or biochips. In this article, we discuss recent advances in this field and compare possible approaches toward single molecule detection.

Keywords

BiomedicalNanoparticleSensor
Type
Outstanding Meeting Paper—Article
Information
Journal of Materials Research , Volume 20 , Issue 12 , December 2005 , pp. 3294 - 3302
Copyright
Copyright © Materials Research Society 2005

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