Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-10T21:12:47.130Z Has data issue: false hasContentIssue false
  • English
  • Français

The mineralization of polymer electrospun fibrous membranes modified with tourmaline nanoparticles

Published online by Cambridge University Press:  04 March 2019

Jinsheng Liang ,
Na Hui ,
Tianyu Zhao  and
Hong Zhang Open the ORCID record for Hong Zhang [Opens in a new window]
Jinsheng Liang
Affiliation:
Key Laboratory of Special Functional Materials for Ecological Environment and Information (Hebei University of Technology), Ministry of Education, Tianjin 300130, China; Institute of Power Source and Ecomaterials Science, Hebei University of Technology, Tianjin 300130, China; and Key Laboratory for New Type of Functional Materials in Hebei Province, Hebei University of Technology, Tianjin 300130, China
Na Hui
Affiliation:
Key Laboratory of Special Functional Materials for Ecological Environment and Information (Hebei University of Technology), Ministry of Education, Tianjin 300130, China; Institute of Power Source and Ecomaterials Science, Hebei University of Technology, Tianjin 300130, China; and Key Laboratory for New Type of Functional Materials in Hebei Province, Hebei University of Technology, Tianjin 300130, China
Tianyu Zhao
Affiliation:
Key Laboratory of Special Functional Materials for Ecological Environment and Information (Hebei University of Technology), Ministry of Education, Tianjin 300130, China; Institute of Power Source and Ecomaterials Science, Hebei University of Technology, Tianjin 300130, China; and Key Laboratory for New Type of Functional Materials in Hebei Province, Hebei University of Technology, Tianjin 300130, China
Hong Zhang*
Affiliation:
Key Laboratory of Special Functional Materials for Ecological Environment and Information (Hebei University of Technology), Ministry of Education, Tianjin 300130, China; Institute of Power Source and Ecomaterials Science, Hebei University of Technology, Tianjin 300130, China; and Key Laboratory for New Type of Functional Materials in Hebei Province, Hebei University of Technology, Tianjin 300130, China
*
a)Address all correspondence to this author. e-mail: zhanghong@hebut.edu.cn
Get access

Abstract

As distinctive spontaneous polarization and far-infrared radiation characteristics, the natural mineral tourmaline (TM) has the regulatory effect on crystallization behavior, which possesses potential application in biomimetic mineralization and bone regeneration. In this study, polyurethane (PU) and gelatin (GE) membranes with different adding proportion of TM nanoparticles were prepared via electrospinning. Additionally, the effect of TM nanoparticles on the mineralization process of hydrophobic PU and hydrophilic GE was investigated by immersing the composite TM/PU and TM/GE electrospun membranes in the 10× simulated body fluid (10SBF) at 37 °C for varying periods of time. SEM images confirmed the well-dispersed TM nanoparticles in the PU and GE electrospun fibers. The mineralization deposition was characterized by the SEM, EDS, XRD, and FTIR, and it indicated that two types of calcium phosphate deposits with different Ca/P molar ratios were obtained when TM/PU membranes and TM/GE membranes were incubated in 10SBF. Honeycomb-like hydroxyapatite crystals nucleated and grew faster on TM/PU and TM/GE membranes than the pure PU and GE membranes, respectively. Furthermore, with the increase of the added TM nanoparticles in the composite membranes, more calcium phosphate crystals were precipitated. These results showed that the added TM nanoparticles were able to improve the mineralization of polymer fibrous membranes, which is potential for the composite bone scaffold.

Keywords

tourmaline nanoparticlespolyurethanegelatinelectrospinningmineralization
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 11: Focus Issue: (Nano)materials for Biomedical Applications , 14 June 2019 , pp. 1900 - 1910
Copyright
Copyright © Materials Research Society 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Rustom, L.E., Poellmann, M.J., and Wagoner Johnson, A.J.: Mineralization in micropores of calcium phosphate scaffolds. Acta Biomater. 83, 435–455 (2019).CrossRefGoogle ScholarPubMed
Braem, A., Chaudhari, A., Vivan Cardoso, M., Schrooten, J., Duyck, J., and Vleugels, J.: Peri- and intra-implant bone response to microporous Ti coatings with surface modification. Acta Biomater. 10, 986–995 (2014).CrossRefGoogle ScholarPubMed
Xiu, P., Jia, Z., Lv, J., Yin, C., Cai, H., Song, C., Leng, H., Zheng, Y., Liu, Z., and Cheng, Y.: Hierarchical micropore/nanorod apatite hybrids in situ grown from 3-D printed macroporous Ti6Al4V implants with improved bioactivity and osseointegration. J. Mater. Sci. Technol. 33, 179–186 (2017).CrossRefGoogle Scholar
Jose, M.V., Thomas, V., Johnson, K.T., Dean, D.R., and Nyairo, E.: Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineering. Acta Biomater. 5, 305–315 (2009).CrossRefGoogle ScholarPubMed
Ko, J.H., Yin, H.Y., An, J., and Chung, D.J.: Characterization of cross-linked gelatin nanofibers through electrospinning. Macromol. Res. 18, 137–143 (2010).CrossRefGoogle Scholar
Jin, Y., Yang, D., Zhou, Y., Ma, G., and Nie, J.: Photocrosslinked electrospun chitosan-based biocompatible nanofibers. J. Appl. Polym. Sci. 109, 3337–3343 (2008).CrossRefGoogle Scholar
Zhang, H., Jia, X., Han, F., Zhao, J., Zhao, Y., Fan, Y., and Yuan, X.: Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration. Biomaterials 34, 2202–2212 (2013).CrossRefGoogle ScholarPubMed
Herrero-Herrero, M., Gómez-Tejedor, J.A., and Vallés-Lluch, A.: PLA/PCL electrospun membranes of tailored fibres diameter as drug delivery systems. Eur. Polym. J. 99, 445–455 (2018).CrossRefGoogle Scholar
Hiep, N.T. and Lee, B.T.: Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility. J. Mater. Sci.: Mater. Med. 21, 1969–1978 (2010).Google ScholarPubMed
Yan, L.D., Si, S.X., Chen, Y., Yuan, T., Fan, H.J., Yao, Y.Y., and Zhang, Q.Y.: Electrospun in situ hybrid polyurethane/nano-TiO2 as wound dressings. Fibers Polym. 12, 207–213 (2011).CrossRefGoogle Scholar
Nguyen, T.H., Padalhin, A.R., Seo, H.S., and Lee, B.T.: A hybrid electrospun PU/PCL scaffold satisfied the requirements of blood vessel prosthesis in terms of mechanical properties, pore size, and biocompatibility. J. Biomater. Sci., Polym. Ed. 24, 1692–1706 (2013).CrossRefGoogle ScholarPubMed
Ritfeld, G.J., Rauck, B.M., Novosat, T.L., Park, D., Patel, P., Roos, R.A., Wang, Y., and Oudega, M.: The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair. Biomaterials 35, 1924–1931 (2014).CrossRefGoogle Scholar
Angeloni, V., Contessi, N., De, C.M., Bertoldi, S., Tanzi, M.C., and Farè, S.: Polyurethane foam scaffold as in vitro model for breast cancer bone metastasis. Acta Biomater. 63, 306–316 (2017).CrossRefGoogle ScholarPubMed
Wang, H., Feng, Y., Zhao, H., Xiao, R., Lu, J., Zhang, L., and Guo, J.: Electrospun hemocompatible PU/gelatin-heparin nanofibrous bilayer scaffolds as potential artificial blood vessels. Macromol. Res. 20, 347–350 (2012).CrossRefGoogle Scholar
Xu, W., Wang, Z., Liu, Y., Wang, L., Jiang, Z., Li, T., Zhang, W., and Liang, Y.: Carboxymethyl chitosan/gelatin/hyaluronic acid blended-membranes as epithelia transplanting scaffold for corneal wound healing. Carbohydr. Polym. 192, 240–250 (2018).CrossRefGoogle ScholarPubMed
Sattary, M., Khorasani, M.T., Rafienia, M., and Rozve, H.S.: Incorporation of nanohydroxyapatite and vitamin D3 into electrospun PCL/Gelatin scaffolds: The influence on the physical and chemical properties and cell behavior for bone tissue engineering. Polym. Adv. Technol. 29, 451–462 (2018).CrossRefGoogle Scholar
Nagarajan, S., Belaid, H., Pochat-Bohatier, C., Teyssier, C., Iatsunskyi, I., Coy, E., Balme, S., Cornu, D., Miele, P., Kalkura, N.S., Cavaillès, V., and Bechelany, M.: Design of boron nitride/gelatin electrospun nanofibers for bone tissue engineering. ACS Appl. Mater. Interfaces 9, 33695–33706 (2017).CrossRefGoogle ScholarPubMed
Yao, S., Jin, B., Liu, Z., Shao, C., Zhao, R., Wang, X., and Tang, R.: Biomineralization: From material tactics to biological strategy. Adv. Mater. 29, 1605903 (2017).CrossRefGoogle ScholarPubMed
Cai, Q., Feng, Q., Liu, H., and Yang, X.: Preparation of biomimetic hydroxyapatite by biomineralization and calcination using poly(l-lactide)/gelatin composite fibrous mat as template. Mater. Lett. 91, 275–278 (2013).CrossRefGoogle Scholar
Rajzer, I., Menaszek, E., Kwiatkowski, R., Planell, J.A., and Castano, O.: Electrospun gelatin/poly(ε-caprolactone) fibrous scaffold modified with calcium phosphate for bone tissue engineering. Mater. Sci. Eng., C 44, 183–190 (2014).CrossRefGoogle ScholarPubMed
Chen, J., Chu, B., and Hsiao, B.S.: Mineralization of hydroxyapatite in electrospun nanofibrous poly (L-lactic acid) scaffolds. J. Biomed. Mater. Res., Part A 79, 307–317 (2006).CrossRefGoogle ScholarPubMed
Yang, F., Wolke, J.G.C., and Jansen, J.A.: Biomimetic calcium phosphate coating on electrospun poly(ɛ-caprolactone) scaffolds for bone tissue engineering. Chem. Eng. J. 137, 154–161 (2008).CrossRefGoogle Scholar
Meng, Z., Li, H., Sun, Z., Zheng, W., and Zheng, Y.: Fabrication of mineralized electrospun PLGA and PLGA/gelatin nanofibers and their potential in bone tissue engineering. Mater. Sci. Eng., C 33, 699–706 (2013).CrossRefGoogle ScholarPubMed
Yeh, J.T., Hsiung, H.H., Wei, W., Zhu, P., Chen, K.N., and Jiang, T.: Negative air ion releasing properties of tourmaline/bamboo charcoal compounds containing ethylene propylene diene terpolymer/polypropylene composites. J. Appl. Polym. Sci. 113, 1097–1110 (2009).CrossRefGoogle Scholar
Tijing, L.D., Ruelo, M.T.G., Amarjargal, A., Pant, H.R., Park, C.H., Kim, D.W., and Kim, C.S.: Antibacterial and superhydrophilic electrospun polyurethane nanocomposite fibers containing tourmaline nanoparticles. Chem. Eng. J. 197, 41–48 (2012).CrossRefGoogle Scholar
Zhang, H., Lv, A., Liang, J., and Meng, J.: The preparation of TiO2 composite materials modified with Ce and tourmaline and the study of their photocatalytic activity. RSC Adv. 5, 55704–55712 (2015).CrossRefGoogle Scholar
Zhang, H., Li, P., Hui, N., and Liang, J.: PLCL electrospun fibers improved with tourmaline particles to prevent thrombosis. J. Controlled Release 259, e44–e45 (2017).CrossRefGoogle Scholar
Qiu, S., Ma, F., Yuan, W., and Xu, S.: Study on the biological effect of tourmaline on the cell membrane of E. coli. Surf. Interface Anal. 43, 1069–1073 (2011).CrossRefGoogle Scholar
Jiang, S.Y., Radvane, M., Nakamura, E., Palmer, M., Kobayashi, K., Zhao, H., and Zhao, K.: Chemical and boron isotopic variations of tourmaline in the Hnilec granite-related hydrothermal system, Slovakia: Constraints on magmatic and metamorphic fluid evolution. Lithos 106, 1–11 (2018).CrossRefGoogle Scholar
Wei, L., Ma, F., Wang, Q., Wang, H., and Zhang, X.: Investigation of the reduction performance of sulfate reducing bacteria enhanced by nano-meter/submicron tourmaline. J. Biotechnol. 136, S142 (2008).CrossRefGoogle Scholar
Sekara, C., Kanchana, P., Nithyaselvi, R., and Girija, E.K.: Effect of fluorides (KF and NaF) on the growth of dicalcium phosphate dihydrate (DCPD) crystal. Mater. Chem. Phys. 115, 21–27 (2009).CrossRefGoogle Scholar
Zhang, C., Zhang, W., Mao, L., Zhao, Y., and Yu, S.: Biomimetic mineralization of zein/calcium phosphate nanocomposite nanofibrous mats for bone tissue scaffolds. CrystEngComm 16, 9513–9519 (2014).CrossRefGoogle Scholar
Zhao, J., Zhao, Y., Zhang, W., Yuan, X., and Yao, K.: Preparation and mineralization of PLGA/Gt electrospun fiber mats. Chin. Sci. Bull. 54, 1328–1333 (2009).Google Scholar
Supplementary material: File

Liang et al. supplementary material

Figure S1

Download Liang et al. supplementary material(File)
File 31 KB