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Mono and dialkoxysilane surface modification of superparamagnetic iron oxide nanoparticles for application as magnetic resonance imaging contrast agents

Published online by Cambridge University Press:  03 July 2012

Brian A. Larsen ,
Kendall M. Hurst ,
W. Robert Ashurst ,
Natalie J. Serkova  and
Conrad R. Stoldt
Brian A. Larsen
Affiliation:
Department of Mechanical Engineering, University of Colorado, Boulder, Colorado 80401
Kendall M. Hurst
Affiliation:
Department of Chemical Engineering, Auburn University, Auburn, Alabama 36849
W. Robert Ashurst
Affiliation:
Department of Chemical Engineering, Auburn University, Auburn, Alabama 36849
Natalie J. Serkova
Affiliation:
Department of Anesthesiology, University Cancer of Colorado Center Imaging Core, Anschutz Medical Center, Aurora, Colorado 80045
Conrad R. Stoldt*
Affiliation:
Department of Mechanical Engineering, University of Colorado, Boulder, Colorado 80401
*
a)Address all correspondence to this author. e-mail: conrad.stoldt@colorado.edu
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Abstract

In this study, we have developed and characterized two previously unstudied alkoxysilane surface chemistries for use with superparamagnetic iron oxide (SPIO) nanoparticles as a magnetic resonance imaging contrast agent. We modified superparamagnetic iron oxide nanoparticles (SPIO) using aminopropyl triethoxysilane and two analogous alkoxysilanes, aminopropyl dimethylethoxysilane and aminopropyl methyldiethoxysilane, to compare a mono- and dialkoxysilane, respectively, to a more commonly used trialkoxysilane as two new SPIO surface chemistries capable of forming ultrathin functional surface coatings. The ligand densities of the mono- and dialkoxysilane-modified SPIO produced in this study are consistent with near monolayers of ligands on the SPIO surface. We studied the chemical stability of the mono-, di-, and trialkoxysilane-modified SPIO in neutral and acidic media to evaluate the viability of these surface chemistries for use in long-term intracellular applications. The mono- and dialkoxysilane-modified SPIO demonstrate comparable chemical stability to the trialkoxysilane-modified SPIO, indicating that the mono- and dialkoxysilane are both viable new SPIO surface chemistries for future applications requiring minimally thick alkoxysilane surface coatings.

Type
Articles
Information
Journal of Materials Research , Volume 27 , Issue 14 , 28 July 2012 , pp. 1846 - 1852
Copyright
Copyright © Materials Research Society 2012

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