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Monodisperse Au/aminosilica composite nanospheres: Facile one-step synthesis and their applications in gene transfection

Published online by Cambridge University Press:  11 July 2012

Lei Wang ,
Tuck-yun Cheang ,
Shenming Wang ,
Zuojun Hu ,
Zhouhao Xing ,
Wengang Qu  and
Anwu Xu
Lei Wang
Affiliation:
Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China
Tuck-yun Cheang
Affiliation:
Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
Shenming Wang
Affiliation:
Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
Zuojun Hu
Affiliation:
Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
Zhouhao Xing
Affiliation:
Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China
Wengang Qu
Affiliation:
Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China
Anwu Xu*
Affiliation:
Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China
*
a)Address all correspondence to this author. e-mail: anwuxu@ustc.edu.cn
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Abstract

In this study, Au/aminosilica composite nanospheres have been synthesized via a simple one-pot route using HAuCl4 and N-(3-trimethoxysilylpropyl)-ethylenediamine as starting materials. Scanning electron microscopy results show that these spheres are with diameters of about 300 nm. The obtained Au/aminosilica nanospheres were used as nonviral carriers for gene delivery. Compared with commercial Lipofectamine 2000, the Au/aminosilica nanospheres are with higher transfection efficiency and lower cytotoxicity. Furthermore, the nanospheres are biocompatible, which may find applications in gene delivery and drug carrier.

Keywords

Aubiomaterialcomposite
Type
Articles
Information
Journal of Materials Research , Volume 27 , Issue 18 , 28 September 2012 , pp. 2425 - 2430
Copyright
Copyright © Materials Research Society 2012

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