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A nanoindentation technique for functional evaluation of cartilage repair tissue

Published online by Cambridge University Press:  03 March 2011

Donna M. Ebenstein ,
Alfred Kuo ,
Juan J. Rodrigo ,
A. Hari Reddi ,
Michael Ries  and
Lisa Pruitt
Donna M. Ebenstein
Affiliation:
Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, California 94143
Alfred Kuo
Affiliation:
Department of Orthopaedic Surgery, University of California at Davis, Sacramento, California 95817
Juan J. Rodrigo
Affiliation:
Department of Orthopaedic Surgery, University of California at Davis, Sacramento, California 95817
A. Hari Reddi
Affiliation:
Department of Orthopaedic Surgery, University of California at Davis, Sacramento, California 95817
Michael Ries
Affiliation:
Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, California 94143
Lisa Pruitt
Affiliation:
Departments of Bioengineering and Mechanical Engineering, University of California at Berkeley, Berkeley, California 94720
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Abstract

Cartilage repair is an ongoing challenge in orthopaedic research. Both biological and mechanical properties are needed for full functional characterization of a tissue replacement. However, assessment of cartilage repair tissue has relied primarily on histological markers because mechanical properties are difficult to measure in small tissue regions. Nanoindentation is a technique that is specialized for measuring local mechanical properties in small specimens. In this study, nanoindentation was used to measure the mechanical properties of cartilage repair tissue following microfracture treatment of chondral defects in three rabbit knees. The mechanical properties were then correlated with histology findings from the same tissue samples. Nanoindentation provided complementary information to histology. In particular, the nanoindentation results showed that the mechanical properties of the repair tissue were inferior to the control tissue properties, even though some tissue regions were histologically similar to the control tissue.

Keywords

NanoindentationMechanical propertiesBiological
Type
Articles
Information
Journal of Materials Research , Volume 19 , Issue 1 , January 2004 , pp. 273 - 281
Copyright
Copyright © Materials Research Society 2004

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