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Self-assembled lipid nanotubes by rational design

Published online by Cambridge University Press:  28 January 2011

Thomas Barclay ,
Kristina Constantopoulos  and
Janis Matisons
Thomas Barclay
Affiliation:
Nanomaterials Group, School of Chemical & Physical Sciences, Flinders University, Adelaide, South Australia, 5001, Australia
Kristina Constantopoulos
Affiliation:
Nanomaterials Group, School of Chemical & Physical Sciences, Flinders University, Adelaide, South Australia, 5001, Australia
Janis Matisons*
Affiliation:
Nanomaterials Group, School of Chemical & Physical Sciences, Flinders University, Adelaide, South Australia, 5001, Australia
*
a)Address all correspondence to this author. e-mail: jmatisons@gelest.com
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Abstract

Five lipids were self-assembled in aqueous dispersions into high axial ratio nanostructures. Thermal analysis was conducted on a glycolipid self-assembled into nanotubes, previously developed by Kamiya et al. [S. Kamiya, H. Minamikawa, J-H. Jung, B. Yang, M. Masuda, and T. Shimizu, Langmuir21, 743 (2005)], showing a dry melting onset of 148.2 °C and evidence of a highly ordered supramolecular structure. A novel hybrid structure of the glycolipid nanotubes decorated with silver nanoparticles was created. The self-assembly of four new amphiphiles, with serine and glutamic acid head groups attached to vaccenic acid and diacetylenic hydrophobic tails, was also investigated. The morphologies of these aggregates included high axial ratio nanostructures, such as nanotubes; and flat, twisted, and helical ribbons. The supramolecular aggregates of the five lipids reflect aspects of the molecular structure, such as chirality, providing evidence that such organized aggregates can be created by a rational approach to molecular design.

Keywords

Biomimetic (assembly)NanostructureSelf-Assembly
Type
Reviews
Information
Journal of Materials Research , Volume 26 , Issue 2: Focus Issue: Self-Assembly and Directed Assembly of Advanced Materials , 28 January 2011 , pp. 322 - 335
Copyright
Copyright © Materials Research Society 2011

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