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Spherical indentation of lungs: Experiments, modeling and sub-surface imaging

Published online by Cambridge University Press:  31 January 2011

Maricris R. Silva ,
Zhijia Yuan ,
Jae Hun Kim ,
Zhenguo Wang ,
Melissa Hoyos ,
Yingtian Pan  and
Andrew Gouldstone
Maricris R. Silva
Affiliation:
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02199
Zhijia Yuan
Affiliation:
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794
Jae Hun Kim
Affiliation:
Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York 11794
Zhenguo Wang
Affiliation:
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794
Melissa Hoyos
Affiliation:
Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York 11794
Yingtian Pan
Affiliation:
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794
Andrew Gouldstone*
Affiliation:
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02199
*
b) Address all correspondence to this author. e-mail: agouldstone@coe.neu.edu
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Abstract

Knowledge of mechanics in atelectasis (alveolar collapse) and reinflation would be useful during anesthesia and critical care. Here an investigation is presented in which atelectasis is induced in a controlled manner on excised inflated lungs using spherical indentation, and noninvasive imaging of the deformed subsurface region is performed using optical coherence tomography (OCT). Indentation loads are physiologic, and spatial dimensions are far larger than alveolar size to allow continuum discussions. Experimental observations of atelectasis are compared with finite element model calculations of maximum stresses. Finally, atelectasis is compared during inflation of lungs with different gases (e.g., air, oxygen/anesthesia mixture).

Keywords

BiologicalHardnessOptical
Type
Articles
Information
Journal of Materials Research , Volume 24 , Issue 3 , March 2009 , pp. 1156 - 1166
Copyright
Copyright © Materials Research Society 2009

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