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The Effect of Flow Velocity on Microcantilever-Based Biosensors

Published online by Cambridge University Press:  05 May 2011

M.-C. Wu ,
J.-S. Chang ,
K.-C. Wu ,
C.-H. Lin  and
C.-Y. Wu
M.-C. Wu*
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan 10617, R.O.C.
J.-S. Chang*
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan 10617, R.O.C.
K.-C. Wu*
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan 10617, R.O.C.
C.-H. Lin*
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan 10617, R.O.C.
C.-Y. Wu*
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan 10617, R.O.C.
*
*Graduate student
**Professor
**Professor
*Graduate student
***Ph.D. student
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Abstract

This work focuses on studying the effect of flow velocity on microcantilever-based biosensor by numerical simulation. The microcantilever sensors used in detecting biomolecules have attractive advantages like cost efficiency, real-time and ability of fabricating in array. Both rectangular and triangular shapes of a general model of microcantilever beam are considered. Several important physical phenomena are obtained. Comparing with the first order Langmuir theory, we have calculated the effect on the reactive rate, produced concentration, the distribution of concentration and deflection in the z axis by solving these physical coupled problem involving flow field, concentration field and chemical reaction on the reaction surface. It is found numerically that the transportation of analyte, reactive rate, the distribution of concentration and deflection in the z axis are all effected by changing the flow velocity. The result has shown that flow velocity is an important factor for this biosensor.

Keywords

MicrocantileverBiosensorFinite element method
Type
Articles
Information
Journal of Mechanics , Volume 23 , Issue 4 , December 2007 , pp. 353 - 358
Copyright
Copyright © The Society of Theoretical and Applied Mechanics, R.O.C. 2007

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References

1.Battiston, F. M., Ramseyer, J. P., Lang, H. P., Baller, M. K., Gerber, Ch., Gimzewski, J. K., Meyer, E. and Guntherodt, H. J., “A Chemical Sensor Based on a Microfabricated Cantilever Array With Simultaneous Resonance-Frequency and Bending Readout,” Sensor and Actuators B, 77, pp.122–131 (2001).CrossRefGoogle Scholar
2.Yoo, K. A., Na, K. H., Joung, S. R., Nahm, B. H., Kang, C. J. and Kim, Y. S., “Microcantilever-Based Biosensor for Detection of Various Biomolecules,” Japanese Journal of Applied Physics, 45, 1B, pp.515–518 (2006).CrossRefGoogle Scholar
3.Moulin, A. M., O'Shea, S. J. and Welland, M. E., “Microcantilever-Based Biosensors,” Ultramicroscopy, 82, pp. 23–31 (2000).CrossRefGoogle ScholarPubMed
4.Berger, R., Delamarche, E., Lang, H. P., Gerber, C., Gimzewski, J. K., Meyer, E. and Güntherodt, H. J., “Surface Stress in the Self-Assembly of Alkanethiols on Glod,” SCIENCE, 276, pp. 2021–2024 (1997).CrossRefGoogle Scholar
5.Poirier, G. E. and Pylant, E. D., “The Self-Assembly Mechanism of Alkanethiols on Au(111),” Science, New Series, 272(5265), pp. 1145–1148(1996).Google Scholar
6.Raiteri, R., Butt, H. J. and Grattarola, M., “Changes in Surface Stress at Liquid/Solid Interface Measured with a Microcantilever,” Electrochimica Acta, 46, pp. 157–163 (2000).CrossRefGoogle Scholar
7.Wu, G., Datar, R. H., Hansen, K. M., Thundat, T., Cote, R. J. and Majumdar, A., “Bioassay of Prostate-Specific Antigen (PSA) Using Microcantilevers,” Nature Biotechnology, 19, pp. 856–860(2001).CrossRefGoogle ScholarPubMed
8.Wu, G., Ji, H., Hansen, K., Thundat, T., Datar, R., Cote, R., Hagan, M. F., Chakraborty, A. K. and Majumdar, A., “Origin of Nanomechanical Cantilever Motion Generated from Biomolecular Interactions,” Proceedings of the National Academy of Sciences of the United States of America 98, pp. 1560–1564 (2001).CrossRefGoogle ScholarPubMed
9.Langmuir, I., “The Adsorption of Gases on Plane Surfaces of Glass, Mica and Platinum,” J. Am. Chem. Soc., 40, pp. 1361–1403 (1918).CrossRefGoogle Scholar
10.Ilkovic, D., Collect. Czech. Chem. Commun., 6, p.498 (1934)CrossRefGoogle Scholar
11.Rahn, J. R. and Hallock, R. B., “Antibody Binding to Antigen-Coated Substrates Studied with Surface Plasmon Oscillations,” Langmuir, 11, pp. 650–654 (1995).CrossRefGoogle Scholar
12.Camillone, Nicholas, “Diffusion-Limited Thiol Adsorption on the Gold(111) Surface,” Langmuir, 20, pp. 1199–1206(2004).CrossRefGoogle ScholarPubMed
13.Jung, L. S. and Campbell, C. T., “Sticking Probabilities in Adsorption of Alkylthiols from Liquid Ethanol Solution onto Gold,” J. Phys. Chem. B, 104, pp. 11168–1117(2000).CrossRefGoogle Scholar