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Effects of 5-Hydroxytryptophan on Schizophrenia

Published online by Cambridge University Press:  08 February 2018

J. C. Brengelmann ,
C. M. B. Pare  and
M. Sandler
J. C. Brengelmann
Affiliation:
Institute of Psychiatry, Maudsley Hospital, London, S.E.5
C. M. B. Pare
Affiliation:
Bethlem Royal and the Maudsley Hospital, London, S.E.5
M. Sandler
Affiliation:
Royal Free Hospital, London, W.C.1
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Extract

The present investigation represents a logical continuation of a previous experiment where it was shown that the injection of 5-hydroxytryptophan (5HTP) alleviates the psychological effects of lysergic acid diethylamide (LSD-25) (Brengelmann, Pare and Sandler, 1958). LSD is of interest in psychiatry because the psychotomimetic effects of the drug bear a resemblance to schizophrenia clinically, in psychological tests and, according to Hoagland, Rinkel and Hyde (1955), in their abnormal excretion of urinary phosphate. The possibility presents itself that, in some cases of schizophrenia, the functional abnormality is similar to that produced by LSD.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 440 , July 1959 , pp. 770 - 776
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

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