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A Clinical and Biochemical Study of Monoamine Oxidase Inhibition in Depressed Patients

Ii. 5-Hydroxytryptamine Tolerance Before and After Nialamide

Published online by Cambridge University Press:  08 February 2018

W. G. Dewhurst  and
C. M. B. Pare
W. G. Dewhurst
Affiliation:
Bethlem Royal and The Maudsley Hospitals
C. M. B. Pare
Affiliation:
Bethlem Royal and The Maudsley Hospitals
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Extract

In order to test whether a drug is an inhibitor of monoamine oxidase in the human subject, three main measures are available:

1. We can measure an increased excretion of the normal substrates of the enzyme, e.g. tryptamine (Sjoerdsma, et al., 1959b).

2. We can measure a decreased excretion of the metabolites resulting from the enzyme's action, e.g. 5-hydroxyindoleacetic acid (5-HIAA).

3. We can administer a loading dose of an enzyme substrate and observe how the subject deals with it before and after the drug, e.g. 5-hydroxytryptamine (Sjoerdsma et al., 1958), and epinephrine (N-methyl-C14) (Resnick et al., 1958).

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 447 , March 1961 , pp. 244 - 249
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

Dewhurst, W. G., and Pare, C. M. B. (to be published).Google Scholar
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