Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-14T04:53:00.354Z Has data issue: false hasContentIssue false
  • English
  • Français

The Clinical Manifestations of Depressive Illness with Abnormal Acetyl Methyl Carbinol Metabolism

Published online by Cambridge University Press:  08 February 2018

W. Mcc. Anderson  and
J. Dawson
W. Mcc. Anderson
Affiliation:
Runwell Hospital, Wickford, Essex
J. Dawson
Affiliation:
Medical Research Council
Get access Rights & Permissions [Opens in a new window]

Extract

The fasting blood acetyl methyl carbinol (A.M.C.) level was shown to be high at the start of the depressive phase in manic-depressives by Dawson, Hullen and Crockett (1). Such cases also showed large fluctuations of fasting blood A.M.C. level compared with normals. The findings in a manic-depressive patient investigated more recently are shown in Figure 1; those in a normal female are given also for comparison. In the manic-depressive, it can be seen that the fasting blood A.M.C. level tended to fluctuate widely, to be high before and at the start of a depressive phase. There is no evidence to suggest that A.M.C. in the quantities found could cause psychiatric manifestations (Stotz, Westerfeld and Berg, 8). It is hence possible that the alterations in A.M.C. level were merely an indication of an abnormal variability of some part of the biochemical milieu. It was decided therefore to investigate patients with other forms of depressive illness to see whether or not abnormalities of A.M.C. level and variability were present, similar to those in manic-depressives.

Type
Original Articles
Information
Journal of Mental Science , Volume 108 , Issue 452 , January 1962 , pp. 80 - 87
Copyright
Copyright © Royal College of Psychiatrists, 1962 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Dawson, J., Hullen, R. P., and Crockett, B. M., J. Ment. Sci., 1956, 102, 168.Google Scholar
2. Iidem and Pool, A., ibid., 1954, 100, 536.Google Scholar
3. Happold, F. C., and Spencer, C. P., Biochem. Biophys. Acta, 1952, 8, 18.Google Scholar
4. Henderson, D. K., and Gillespie, R. D., A Textbook of Psychiatry, 1956. London: Oxford University Press.Google Scholar
5. Lewis, A. J., J. Ment. Sci., 1934, 80, 277.Google Scholar
6. Mayer-Gross, W., Slater, E., and Roth, M., Clinical Psychiatry, 1960. London: Casse 11 & Co. Google Scholar
7. Mendelson, M., Brit. J. Med. Psychol., 1959, 32, 183.Google Scholar
8. Stotz, E., Westerfeld, W. W., and Berg, R. L., J. Biol. Chem., 1944, 152, 41.Google Scholar
9. Strauss, E. B., in Symposium on Depression, May 1960, at Royal College of Surgeons, London, 1960. In the press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.