Hostname: page-component-745bb68f8f-d8cs5 Total loading time: 0 Render date: 2025-01-11T02:11:58.308Z Has data issue: false hasContentIssue false
  • English
  • Français

Differential Effects of Lysergic Acid and Sodium Amytal on Immediate Memory and Expressive Movement

Published online by Cambridge University Press:  08 February 2018

J. C. Brengelmann ,
S. G. Laverty  and
D. J. Lewis
J. C. Brengelmann
Affiliation:
Institute of Psychiatry, Maudsley Hospital, Denmark Hill, London, S.E.5
S. G. Laverty
Affiliation:
Institute of Psychiatry, Maudsley Hospital, Denmark Hill, London, S.E.5
D. J. Lewis
Affiliation:
Institute of Psychiatry, Maudsley Hospital, Denmark Hill, London, S.E.5
Get access Rights & Permissions [Opens in a new window]

Extract

This investigation deals with relationships of sodium amytal and lysergic acid (LSD) to measures of immediate memory and expressive movement as a function of exposure time. Significant differences in learning and expressive movement had been obtained previously between neurotics and schizophrenics (3, 4). The extent of these differences posed the problem why memory disturbance, as in the test, is clinically not more obvious in schizophrenics than in neurotics. It was thought that accidentally favourable conditions had been used, either in difficulty of task or in exposure time, to produce the results. The decision was taken to vary the exposure time in a pilot experiment, using LSD in normals to represent schizophrenic-like symptoms.

Type
Original Articles
Information
Journal of Mental Science , Volume 104 , Issue 434 , January 1958 , pp. 144 - 152
Copyright
Copyright © Royal College of Psychiatrists, 1958 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literature

1. Abramson, H. A., Jarvik, M. E., and Hirsch, M. W., “Lysergic acid diethylamide (LSD-25): VIII. Effect upon two measures of motor performance”, J. Psychol., 1955, 39, 455–464.Google Scholar
2. Idem , Waxenberg, S. E., Levine, A., Kaufman, M. R., and Kornetsky, C., “Lysergic acid diethylamide (LSD-25). XIII. Effect on Bender-Gestalt Test performance”, Ibid, 1955, 40, 341–349.Google Scholar
3. Brengelmann, J. C., “Learning in neurotics and psychotics”, Acta. Psychol. (to appear 1957).Google Scholar
4. Idem , “Expressive movement in abnormals, with particular reference to extraversion and psychoticism”, Acta. Psychol. (to appear 1958).Google Scholar
5. Idem , “The effects of exposure time in immediate recall on abnormal and questionnaire criteria of personality”. (Unpublished paper.)Google Scholar
6. Felsinger, von J. M., Lasagna, L., and Beecher, H. K., “The persistence of mental impairment following a hypnotic dose of a barbiturate”, J. Pharmacol and exp. Therap., 1953, 109, 284–291.Google Scholar
7. Gastaut, H., Ferrer, S., and Castells, C., “Action de la diéthylamide de l'acide d-lysergique (LSD-25) sur les fonctions psychiques et l'électroencéphalogramme”, Conf. Neurol., 1953, 13, 102–120.Google Scholar
8. Goodnow, R. E., Beecher, H. K., Brazier, M. A. B., Mosteller, F., and Tagiuri, R., “Physiological performance following a hypnotic dose of a barbiturate”, J. Pharmacol. and exp. Therap., 1951, 102, 55–61.Google Scholar
9. Jarvik, M. E., Abramson, H. A., and Hirsch, M. W., “Lysergic acid diethylamide (LSD-25): VI. Effect upon recall and recognition of various stimuli”, J. Psychol., 1955, 39, 443–454.Google Scholar
10. Layman, J., “Quantitative study of certain changes in schizophrenic patients under sodium amytal”, J. gen. Psychol., 1940, 22, 67–86.Google Scholar
11. Savage, C., “Lysergic acid diethylamide (LSD-25): A clinical-psychological study”, Amer. J. Psychiat., 1952, 108, 896–900.Google Scholar
12. Shagass, C., and Naiman, J., “The sedation threshold, manifest anxiety and some aspects of Ego function”, A.M.A. Arch. Neurol. Psychiat., 1955, 74, 397–406.Google Scholar
13. Sloane, B., and Lovett Doust, J. W., “Psychophysiological investigations in experimental psychoses: results of the exhibition of d-lysergic acid diethylamide to psychiatric patients”, J. Ment. Sci., 1954, 100, 129–144.Google Scholar
14. Venables, P. H., and Tizard, J., “The effect of stimulus light intensity on reaction time of schizophrenics”, Brit. J. Psychol., 1956, 47, 144–145.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.