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Possible Synergistic Effects of the New Thymoleptics in Connection with Poisoning

Published online by Cambridge University Press:  08 February 2018

E. Howarth
E. Howarth*
Affiliation:
Cheadle Royal, Cheadle, Cheshire
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Extract

During recent years, a good deal of attention has been drawn to the therapeutic and toxic effects of the new thymoleptics. Although most of these preparations have had a reasonable clinical trial before being released for general use, it is a fact that hitherto unsuspected toxic effects continue to come to light. Among the more recently discovered side-effects of Tofranil (imipramine) are the occurrence of jaundice and a tendency in certain patients to epileptic fits. Experimentally it has been shown that Tofranil increases the excitability of the brain of rabbits and may evoke convulsant spikes (1), and in a recent article by Leyberg and Denmark (2) it is recorded that in four cases of a relatively small series the dose of the drug had to be reduced on account of epileptic fits.

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 446 , January 1961 , pp. 100 - 103
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

1. Meter, , Owens, and Himwich, , Canad. Psychiat. Ass. J., 1959, 4, s. 113.Google Scholar
2. Leyberg, and Denmark, , J. Ment. Sci., 1959, 105, 1123.Google Scholar
3. Lancaster, and Foster, , B.M.J., 1959, ii, 1458.Google Scholar
4. Clark, J., B.M.J., 1960, i, 1204.Google Scholar
5. Craig, D. D. H., Warner and Co., 1960. Personal Communication.Google Scholar
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