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Treatment of Anxiety States

II.—Clinical Trial of Benactyzine in Anxiety States

Published online by Cambridge University Press:  08 February 2018

G. R. Hargreaves ,
Max Hamilton  and
Julian M. Roberts
G. R. Hargreaves
Affiliation:
Leeds University Department of Psychiatry, the General Infirmary at Leeds
Max Hamilton
Affiliation:
Leeds University Department of Psychiatry, the General Infirmary at Leeds
Julian M. Roberts
Affiliation:
Leeds University Department of Psychiatry, the General Infirmary at Leeds
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Extract

Of all the tranquillizers, it may well be said that benactyzine has had the most chequered history. After its synthesis, a series of most careful experiments on animals demonstrated its ability to reduce or modify behaviour induced by stress. The first clinical trial gave rise to high hopes of its value in treatment but as further trials, more carefully designed, were made the results became increasingly inconclusive.

Type
Original Articles
Information
Journal of Mental Science , Volume 104 , Issue 437 , October 1958 , pp. 1056 - 1061
Copyright
Copyright © Royal College of Psychiatrists, 1958 

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References

Coady, A., and Jewesbury, E. C. O., “A clinical trial of benactyzine hydrochloride ('Suavitil') as a physical relaxant”, Brit. Med. J., 1956, i 485–487.Google Scholar
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Glow, P., Personal communication, 1958.Google Scholar
Hamilton, M., “The rating of anxiety states”, 1958. In press.Google Scholar
Hargreaves, G. R., Hamilton, M., and Roberts, J. M., “Benactyzine as an aid in treatment of anxiety states”, Brit. Med. J., 1957, i 306–310.CrossRefGoogle Scholar
Jacobsen, N. E., Kehlet, J., Larsen, V., Munkvad, I., and Skinhoj, K., “Investigation into autonomic responses during emotion”, Acta Psychiat. Neurol. Scand., 1955, 30, 607–625.Google Scholar
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