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Trimodality approach, using modern radiation techniques, for management of locally advanced adrenocortical carcinoma – case report

Published online by Cambridge University Press:  18 August 2021

André Laranja Open the ORCID record for André Laranja [Opens in a new window]  and
Carolina Ferreira
André Laranja*
Affiliation:
Department of External Radiotherapy, Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Portugal
Carolina Ferreira
Affiliation:
Department of External Radiotherapy, Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Portugal
*
Author for correspondence: Carlos André de Neves Laranja, Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Department of External Radiotherapy, Rua Dr. António Bernardino de Almeida, Porto, 4200-072, Portugal. Tel: +351915477785. E-mails: andrelaranja79@hotmail.com; andre.laranja@ipoporto.min-saude.pt
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Abstract

Background:

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Surgery is the mainstay of treatment, still even after a R0 surgical margins, there is a high risk of recurrence.

Case Presentation:

A 26-year-old female diagnosed with a large functioning ACC treated with a trimodality approach (surgery, radiotherapy and chemotherapy). Postoperative radiotherapy was proposed regarding the high risk of recurrence. A dose of 50.4 Gy in 28 fractions was delivered to the patient using a volumetric-modulated arc therapy plan. Radiotherapy was safe and well tolerated, and no local recurrence was observed so far (13 months after radiotherapy).

Conclusions:

Due to the rarity of ACC and the lack of evidence regarding this entity, therapeutic approach can be challenging. Recent evidence suggests that radiotherapy could have an important role in the therapeutic arsenal.

Keywords

adrenocorticaladjuvant treatmentcarcinomaradiotherapy
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 22 , 2023 , e14
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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