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An investigation of the effect of gold nanoparticles with different concentrations on increasing absorbed dose: an empirical and simulation study

Published online by Cambridge University Press:  29 November 2018

Masoumeh Hoseinnezhad ,
Mohammad Mahdavi ,
Seyyed R. M. Mahdavi  and
Mobarake Mahdavizade
Masoumeh Hoseinnezhad
Affiliation:
Physics Department, University of Mazandaran, Babolsar, Iran
Mohammad Mahdavi*
Affiliation:
Physics Department, University of Mazandaran, Babolsar, Iran
Seyyed R. M. Mahdavi
Affiliation:
Radiation Biology Research Center and Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
Mobarake Mahdavizade
Affiliation:
Radiation Biology Research Center and Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
*
Author for correspondence: Mohammad Mahdavi, Physics Department, University of Mazandaran, Babolsar, Iran. Tel: +98-35302491. E-mail: m.mahdavi@umz.ac.ir
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Abstract

Purpose

The purpose of this study was to determine the dose enhancement factor (DEF) of gold nanoparticles in a dosimeter gel and construct percentage depth dose curves, using the Optical CT system and the Monte Carlo simulation model, to determine the effect of increasing the dose caused by increasing the concentration of gold nanoparticles at depths in the gel.

Materials and methods

The Magic-f Gel was made based on the relevant protocol in the physics lab. To determine the amount of the increase in the absorbed dose, the gold nanoparticles were added to the gel and irradiated. An increase in the dose after adding nanoparticles to the gel vials was estimated both with the Optical CT system and by the Monte Carlo simulation method.

Results

Dose enhancement curves for doses of 2, 4 and 6 Gy were prepared for gel vials without adding nanoparticles, and nanoparticle gels at concentrations 0·17, 3 and 6 mM. Also, the DEF was estimated. For the 0·17 mM molar gel, the DEF for 2, 4 and 6 Gy was 0·7, 0·743 and 0·801, respectively. For the 3 mM gel, it was 1·98, 2·5 and 2·2, and for the 6 mM gel, it was 37·4, 4·24 and 4·71, respectively.

Conclusion

The enhancement of the dose after adding gold nanoparticles was confirmed both by experimental data and by simulation data.

Keywords

dose enhancement factorEGS-nrc codegold nanoparticleMonte Carlo simulation methodoptical CT
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 18 , Issue 2 , June 2019 , pp. 191 - 197
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Copyright
© Cambridge University Press 2018 

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Footnotes

Cite this article: Hoseinnezhad M, Mahdavi M, Mahdavi SRM, Mahdavizade M. (2019) An investigation of the effect of gold nanoparticles with different concentrations on increasing absorbed dose: an empirical and simulation study. Journal of Radiotherapy in Practice18: 191–197. doi: 10.1017/S1460396918000638

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