Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T08:33:43.586Z Has data issue: false hasContentIssue false
  • English
  • Français

Bilateral breast cancer: a case study

Published online by Cambridge University Press:  15 October 2019

Rajanigandha Tudu Open the ORCID record for Rajanigandha Tudu [Opens in a new window] ,
Anup Kumar ,
Rashmi Singh  and
Payal Raina
Rajanigandha Tudu*
Affiliation:
Department of Radiotherapy, RIMS, Ranchi, India
Anup Kumar
Affiliation:
Department of Radiotherapy, RIMS, Ranchi, India
Rashmi Singh
Affiliation:
Department of Radiotherapy, RIMS, Ranchi, India
Payal Raina
Affiliation:
Department of Radiotherapy, RIMS, Ranchi, India
*
Author for correspondence: Dr Rajanigandha Tudu, RIMS Campus, Bariatu, Ranchi, India. Tel: 8335901633. E-mail: rajanitudu@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Breast cancer is the most common cancer among females worldwide. Increasing breast cancer incidence rates, improved diagnosis and management modalities and growing life expectancy have resulted in increasing numbers of women at risk of developing contralateral primary breast cancer. Bilateral breast cancer can occur synchronously or metachronously.

Material and methods:

This study reports three cases of bilateral breast cancer patients treated at our oncology department between March 2018 and March 2019. The features of presentation, investigation, diagnosis and follow-up care are the highlights of this study.

Results:

Bilateral breast cancer was noted in three patients among the study population in the age group of 35 –55 years. Two of these patients had metachronous bilateral breast cancer, and one patient developed cancer in the second breast during the course of management. The second breast cancers differed histologically from primary breast cancer.

Conclusion:

Poor awareness on breast cancer care and the lack of national screening guidelines and programmes, and poor infrastructure, all contribute to late presentation and difficult breast cancer management. Proper history, clinical examination and imaging of opposite breast should be done to ensure adequate and timely management of bilateral breast cancer.

Keywords

bilateral breast cancermetachronous breast cancerradiationsynchronous breast cancer
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 19 , Issue 3 , September 2020 , pp. 305 - 308
Copyright
© Cambridge University Press 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bray, F I, Ferlay, J, Soerjomataram, I, Siegel, RL, Torre, LA, Jemal, A.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clinicians 2018; 68 (6): 394–424.10.3322/caac.21492CrossRefGoogle ScholarPubMed
Kheirelseid, E A H, Jumustafa, H, Miller, Net al. Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics. Breast Cancer Res Treat 2010; 126 (1): 131–140. doi: 10.1007/s10549-010-1057-yCrossRefGoogle ScholarPubMed
Chaudary, M A, Millis, R R, Hoskins, E Oet al.Bilateral primary breast cancer: a prospective study of disease incidence. Br J Surg 1984; 71 (9): 711–714.CrossRefGoogle ScholarPubMed
Soerjomataram, I, Louwman, W J, Lemmens, V E P P, de Vries, E, Klokman, W J, Coebergh, J W W.Risks of second primary breast and urogenital cancer following female breast cancer in the south of The Netherlands, 1972–2001. Eur J Cancer 2005; 41 (15): 2331–2337.CrossRefGoogle ScholarPubMed
Hill-Kayser, C E, Harris, E R R, Hwang, W T, Solin, L J.Twenty-year incidence and patterns of contralateral breast cancer after breast conservation treatment with radiation. Int J Radiat Oncol Biol Phys 2006; 66 (5): 1313–1319.CrossRefGoogle ScholarPubMed
Gao, X, Fisher, S G, Emami, B.Risk of second primary cancer in the contralateral breast in women treated for early-stage breast cancer: a population-based study. Int J Radiat Oncol Biol Phys 2003; 56 (4): 1038–1045.CrossRefGoogle ScholarPubMed
Kuo, W H, Yen, A M F, Lee, P Het al.Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women. Br J Cancer 2009; 100 (4): 563–570.CrossRefGoogle ScholarPubMed
Chaudery, M A, Mills, R R, Hoskins, E O Let al. Bilateral breast cancer: a prospective study of disease incidence. Br J Surg 1984; 71: 711–714.CrossRefGoogle Scholar
De la Rochefordiere, A, Asselain, B, Scholl, Set al. Simultaneous bilateral breast carcinomas: a retrospective review of 149 cases. Int J Radiat Oncol Biol Phys 1994; 30: 35–41.10.1016/0360-3016(94)90516-9CrossRefGoogle ScholarPubMed
Dawson, L A, Chow, E, Goss, P E. Evolving perspectives in contralateral breast cancer. Eur J Cancer 1998; 34: 2000–2009.CrossRefGoogle ScholarPubMed
Chuba, P J, Hamre, M R, Yap, Jet al. Bilateral risk for subsequent breast cancer after lobular carcinoma in-situ: analysis of surveillance, epidemiology, and end results data. J Clin Oncol 2005; 23: 5534–5541.CrossRefGoogle ScholarPubMed
Bailey, M J, Royce, C, Sloane, J P, Ford, H T, Powles, T J, Gazet, J C. Bilateral carcinoma of the breast. Br J Surg 1980; 67:414–416.CrossRefGoogle ScholarPubMed
Baretta, Z, Olopade, OI, Huo, D.Heterogeneity in hormone-receptor status and survival outcomes among women with synchronous and metachronous bilateral breast cancers. Breast 2015; 24 (2): 131–136. doi:10.1016/j.breast.2014.12.001CrossRefGoogle ScholarPubMed
Whittemore, A S, Gong, G, John, E Met al. Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites. Cancer Epidemiol Biomarkers Prev 2004; 13 (12): 2078–2083.Google ScholarPubMed
Kakarala, M, Wicha, M S.Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol 2008; 26 (17): 2813–2820.CrossRefGoogle ScholarPubMed