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Does body mass index or subcutaneous adipose tissue thickness affect interfraction prostate motion in patients receiving radical prostate radiotherapy?

Published online by Cambridge University Press:  09 September 2016

Jonathan Rogers ,
Camarie Welgemoed  and
Dorothy Gujral
Jonathan Rogers*
Affiliation:
Department of Radiotherapy, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
Camarie Welgemoed
Affiliation:
Department of Radiotherapy, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
Dorothy Gujral
Affiliation:
Department of Radiotherapy, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
*
Correspondence to: Jonathan Rogers, Department of Radiotherapy, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK. Tel: 44 20 8846 7648. E-mail: jonathan.rogers@imperial.nhs.uk
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Abstract

Aim

It is unclear whether body mass index (BMI) is a useful measurement for examining prostate motion. Patient’s subcutaneous adipose tissue thickness (SAT) and weight has been shown to correlate with prostate shifts in the left/right direction. We sought to analyse the relationship between BMI and interfraction prostate movement in order to determine planning target volume (PTV) margins based on patient BMI.

Materials and methods

In all, 38 prostate cancer patients with three implanted gold fiducial markers in their prostate were recruited. Height, mass and SAT were measured, and the extent of interfraction prostate movement in the left/right, superior/inferior and anterior/posterior directions was recorded during each daily fiducial marker-based image-guided radiotherapy treatment. Mean corrective shift in each direction for each patient, along with BMI values, were calculated.

Results

The median BMI value was 28·4 kg/m2 (range 21·4–44·7). Pearson’s product-moment correlation analysis showed no significant relationship between BMI, mass or SAT and the extent of prostate movement in any direction. Linear regression analysis also showed no relationship between any of the patient variables and the extent of prostate movement in any direction (BMI: R2=0·006 (ρ=0·65), 0·002 (ρ=0·80) and 0·001 (ρ=0·86); mass: R2=0·001 (ρ=0·87), 0·010 (ρ=0·54) and 0·000 (ρ=0·99); SAT: R2=0·012 (ρ=0·51), 0·013 (ρ=0·50) and 0·047 (ρ=0·19) for shifts in the X, Y and Z axis, respectively). Patients were grouped according to BMI, as BMI<30 (n=25, 65·8%) and BMI≥30 (n=13, 34·2%). A two-tailed t-test showed no significant difference between the mean prostate shifts for the two groups in any direction (ρ=0·320, 0·839 and 0·325 for shifts in the X, Y and Z axis, respectively).

Findings

BMI is not a useful parameter for determining individualised PTV margins. Gold fiducial marker insertion should be used as standard to improve treatment accuracy.

Keywords

body mass indeximage-guided radiotherapyprostate motionsubcutaneous adipose tissue
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 15 , Issue 4 , December 2016 , pp. 334 - 340
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Copyright
© Cambridge University Press 2016 

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