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Estimation of the risk of secondary malignancies following intraoral electron radiotherapy for tongue cancer patients

Published online by Cambridge University Press:  28 November 2016

Seonghoon Jeong ,
Myonggeun Yoon ,
Weon Kuu Chung ,
Mijoo Chung  and
Dong Wook Kim
Seonghoon Jeong
Affiliation:
Department of Bio-Convergence Engineering, Korea University, Seoul, Korea
Myonggeun Yoon
Affiliation:
Department of Bio-Convergence Engineering, Korea University, Seoul, Korea
Weon Kuu Chung*
Affiliation:
Department of Radiation Oncology, Kyung Hee University Hospital at Gangdong, Seoul, Korea
Mijoo Chung
Affiliation:
Department of Radiation Oncology, Kyung Hee University Hospital at Gangdong, Seoul, Korea
Dong Wook Kim
Affiliation:
Department of Radiation Oncology, Kyung Hee University Hospital at Gangdong, Seoul, Korea
*
Correspondence to: Weon Kuu Chung, Department of Radiation Oncology, Kyung Hee University Hospital at Gangdong, Dongnam-ro 892, Gangdong-Gu, Seoul 134-727, Korea. Tel: +82 2 440 7398. Fax: +82 2 440 7393. E-mail: wkchung@khnmc.or.kr, joocheck@gmail.com
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Abstract

Purpose

To measure dosimetric characteristics for linear accelerator-based electron beams, which are applied through locally manufactured acrylic tubes for intraoral radiotherapy and to calculate the secondary cancer risk for organs at risk.

Materials and methods

Six different acrylic tubes were exposed to a 6-MeV electron beam; they had tips with three angles (0°, 15° and 30°) and two diameters (2·5 and 3·0 cm). Gafchromic EBT2 film was horizontally and vertically inserted in a solid water phantom to measure the dose profiles and percentage depth doses (PDDs). The measured data from radio-photoluminescence glass dosimeters placed on the neck and both eyes were used to estimate the lifetime attributable risk of secondary cancer resulting from intraoral radiotherapy for tongue cancer.

Results

A total of 12 dose profiles were obtained from six different acrylic applicators at 0·5 and 1·28 cm depths. Circular shapes were obtained from 0° applicators, and oval shapes were obtained from 15° and 30° applicators. Absorbed doses at a 0·5 cm depth were higher than those at a 1·28 cm depth. PDD shapes for the six acrylic applicators were similar to those of a normal 6 MeV electron beam. Larger-diameter applicators showed higher PDD than smaller-diameter applicators with the same tip angle. According to our secondary cancer risk estimation, if 100,000 patients received intraoral radiotherapy at 30 years and lived until 80 years, 122 female and 22 male patients would develop secondary thyroid cancer, while 13 female and 18 male patients would develop secondary ocular melanoma or retinoblastoma.

Conclusions

Dosimetric characteristics for linear accelerator-based intraoperative radiotherapy treatment beam were confirmed. In addition, we found that 0·1% of tongue cancer patients would get secondary malignancies for both eyes and thyroid from this treatment.

Keywords

doseelectron radiotherapyintraoral cone radiotherapyradio-photoluminescence glass dosimetersecondary cancer risk
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 16 , Issue 1 , March 2017 , pp. 46 - 52
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Copyright
© Cambridge University Press 2016 

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Footnotes

†

Weon Kuu Chung and Dong Wook Kim equally contributed as corresponding authors.

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