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Evaluation of various dose homogeneity indices for treatment of patients with cervix cancer using intensity-modulated radiation therapy technique

Published online by Cambridge University Press:  09 August 2018

Atia Atiq ,
Maria Atiq ,
Khalid Iqbal ,
Quratul Ain Shamsi  and
Saeed Ahmad Buzdar
Atia Atiq*
Affiliation:
Department of Physics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Maria Atiq
Affiliation:
Department of Physics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Khalid Iqbal
Affiliation:
Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan
Quratul Ain Shamsi
Affiliation:
Department of Physics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Saeed Ahmad Buzdar
Affiliation:
Department of Physics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
*
Author for correspondence: Atia Atiq, Department of Physics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. Tel: +92 33363 87927. E-mail: atiaatiq@hotmail.com
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Abstract

Aim

This study is primarily aimed at the analysis of various dose homogeneity indices (HIs) essential for the evaluation of therapeutic plans by employing intensity-modulated radiation therapy (IMRT) on patients with cervix cancer. Also integral dose (ID) to healthy surrounding organs is computed.

Materials and methods

Effectiveness of different HIs (A, B, C, D) was explored for IMRT plans using 15 MV photon beam. In total, 18 patients were selected at random for treatment of cervix cancer, and dose of 5,040 cGy was delivered in 28 equal fractions.

Results

The study was undertaken to compare four HI formulas and coefficient of determination between each set of HI was known by calculating R2 value. Mean±SD of HI A, HI B, HI C and HI D were 1·12±0·02, 0·13±0·04, 0·10±0·02 and 0·99±0·03, respectively. Mean value of ID for rectum is 3·16 and for bladder is 10·3.

Findings

Our data suggested that HI calculated using four formulas provided good plan quality. The results advocate that all the studied HIs can be effectively used for assessment of uniformity inside the target volume. However, values of HI C were closest to ideal value as compared with other three formulas; hence, it is considered a better measure to compute homogeneity of dose within target volume. The ID gives satisfactory results for surrounding normal tissues such as rectum and bladder and significant critical tissue sparing was achieved by using IMRT technique.

Keywords

cervix cancerhomogeneity indexintegral doseintensity-modulated radiotherapyplanning target volume
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 18 , Issue 1 , March 2019 , pp. 32 - 37
Copyright
© Cambridge University Press 2018 

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Footnotes

Cite this article: Atiq A, Atiq M, Iqbal K, Shamsi QA, Buzdar SA. (2019) Evaluation of various dose homogeneity indices for treatment of patients with cervix cancer using intensity-modulated radiation therapy technique. Journal of Radiotherapy in Practice18: 32–37. doi: 10.1017/S1460396918000249

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