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The incidence of hypothyroidism in patients of head and neck carcinoma treated with radiotherapy and added risk of hypothyroidism with the addition of chemotherapy

Published online by Cambridge University Press:  07 September 2020

Dharmendra Singh Open the ORCID record for Dharmendra Singh [Opens in a new window] ,
Niladri Roy ,
Suparna Kanti Pal ,
Siddhartha Basu  and
Suman Meyur
Dharmendra Singh*
Affiliation:
Department of Radiotherapy, All India Institute of Medical Sciences, Patna, India
Niladri Roy
Affiliation:
Department of Radiotherapy, Medical College and Hospital, Kolkata, India
Suparna Kanti Pal
Affiliation:
Department of Radiotherapy, Bankura Sammilani Medical College, Bankura, West Bengal, India
Siddhartha Basu
Affiliation:
Department of Radiotherapy, Institute of Post Graduate Medical Education and Research, Kolkata, India
Suman Meyur
Affiliation:
Department of Radiotherapy, Institute of Post Graduate Medical Education and Research, Kolkata, India
*
Author for correspondence: Dharmendra Singh, Department of Radiotherapy, All India Institute of Medical Sciences, Phulwarisharif, Patna, Bihar801507, India. E-mail: babu.dsingh.singh35@gmail.com
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Abstract

Background:

Head and neck cancer (HNC) is the most common malignancy in the Indian males. Most of the cases of HNC present in locally advanced stage and requires a multidisciplinary management approach. Radical or adjuvant external beam radiotherapy (EBRT) is one of the important integral components of the management of HNC.

Aim:

To find the incidence of hypothyroidism (HT) in patients of HNC treated with radiotherapy with or without concurrent chemotherapy.

Methods:

A prospective, single institutional longitudinal observational study conducted at the department of radiotherapy, Institute of Post Graduate Medical Education and Research, Kolkata.

Results:

In this study, data of 118 patients were analysed. The median age at presentation was 56 years. The most common primary site of malignancy was oral cavity (39%). The patients were stage I, stage II and stage III as 11, 37·3 and 51·7% respectively. The median dose of EBRT was 66 Gy. HT statistically significantly correlated with primary site of malignancy (p = 0·001), dose of EBRT (p = 0·005). At the end of follow-up of 6 months, 39·8% developed HT.

Conclusion:

The thyroid gland is an important organ at risk while considering EBRT to neck region. The inclusion of thyroid function test in routine follow-up is mandated.

Keywords

Iatrogenic hypothyroidismincidence of hypothyroidismradiation induced hypothyroidism
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 1 , March 2022 , pp. 14 - 20
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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