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The rationale for and the current role of chemoradiotherapy

Published online by Cambridge University Press:  01 March 2007

R. J. Prestwich ,
D. Shakespeare  and
S. Waters
R. J. Prestwich*
Affiliation:
Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, UK
D. Shakespeare
Affiliation:
Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, UK
S. Waters
Affiliation:
Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, UK
*
Correspondance to: Robin James Prestwich MRCP, FRCR, JIF Building, Leeds Institute of Molecular Medicine, St James' University Hospital, Beckett Street, Leeds LS9 7TF, UK. E-mail: rprestwich@doctors.org
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Abstract

Combined-modality treatment using chemotherapy and radiotherapy, particularly concurrently, has now become the standard of care for many solid tumour sites on the basis of improvements in locoregional disease control and in some cases survival. The rationale for combined-modality treatment, potential mechanisms of interaction, the therapeutic ratio and the current place of sequential and concurrent chemoradiotherapy are discussed.

Keywords

Chemotherapyradiotherapychemoradiotherapyinteractionrationale
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 6 , Issue 1 , March 2007 , pp. 11 - 19
Copyright
Copyright © Cambridge University Press 2007

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