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Vertebral compression fracture rate following stereotactic ablative body radiotherapy for spine oligometastases: a UK experience

Published online by Cambridge University Press:  14 April 2021

Sameed Hussain Open the ORCID record for Sameed Hussain [Opens in a new window] ,
Anjali Zarkar ,
Ahmed Elmodir ,
Daniel Ford ,
Sundus Yahya ,
Geoff Heyes ,
Timothy Jackson ,
Ruth Stange ,
Hannah Augustus  and
Jenny Sherriff
Sameed Hussain*
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Anjali Zarkar
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Ahmed Elmodir
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Daniel Ford
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Sundus Yahya
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Geoff Heyes
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Timothy Jackson
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Ruth Stange
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Hannah Augustus
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
Jenny Sherriff
Affiliation:
Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK
*
Author for correspondence: Dr Sameed Hussain, Hall-Edwards Radiotherapy Research Group, Cancer Centre, Queen Elizabeth Hospital, 6 Mindelsohn Way, Birmingham B15 2TH, UK. Tel: 00923005160974. E-mail: drsameed@gmail.com
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Abstract

Aim:

Stereotactic ablative body radiotherapy (SABR) for spine metastases is associated with a risk of vertebral compression fracture (VCF). The aim of this study was to determine the rate of VCF at one UK institution and evaluate the use of the Spinal Instability Neoplastic Score (SINS) to predict these.

Materials and methods:

A retrospective analysis of all patients who underwent SABR for spinal metastases between 2014 and 2018 at one UK institution was performed. Basic demographic data were collected, and SINS prior to SABR was calculated. The primary outcome was VCF rate. Secondary outcomes included time to VCF and need for surgical intervention following VCF.

Results:

A total of 48 oligometastases were treated with a median follow-up of 20·5 months. A maximum of two vertebral bodies were treated. The median baseline SINS was calculated as 3. The median dose was 26 Gy in three fractions. Two patients were reported to have VCF and both were successfully conservatively managed.

Findings:

SABR for spine oligometastases is being performed safely with low VCF rates which are comparable with those in international publications. This may be as a result of strict adherence to criteria for delivery of SABR with low pre-treatment SINS.

Keywords

Vertebral compression fracturespinal stereotactic body radiotherapyspinal instability neoplastic score
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 4 , December 2022 , pp. 476 - 480
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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