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Sensitivity Analysis of the Efficacy of Varenicline in Smoking Cessation With a Special Reference to Study Dropouts

Published online by Cambridge University Press:  21 February 2012

Akira Oshima ,
Yuri Ito  and
Hideki Nomura
Akira Oshima*
Affiliation:
Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan. oosima-ak@mc.pref.osaka.jp
Yuri Ito
Affiliation:
Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
Hideki Nomura
Affiliation:
Kanazawa University Hospital, Japan.
*
*Address for correspondence: Akira Oshima, Cancer Information Services, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1–3–3 Nakamichi, Higashinari-ku, Osaka 537–8511, Japan.
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Abstract

We conducted a sensitivity analysis under four scenarios using data from three Asian studies conducted with low dropout rates to evaluate the efficacy of varenicline in smoking cessation within a scenario where dropouts from the study are dealt with in a manner as unfavourable as possible to varenicline. Pooled odds ratio of continuous abstinence at week 24 was 1.55 (95% confidence interval: 1.03–2.35, random-effect model) under the scenario where dropouts from the varenicline group were dealt with as smokers and those from the placebo group as successful quitters. From the present study, the efficacy of varenicline has been firmly established in the Asian population.

Keywords

efficacysensitivity analysissmoking cessationvarenicline
Type
Articles
Information
Journal of Smoking Cessation , Volume 4 , Issue 2 , 01 December 2009 , pp. 86 - 91
Copyright
Copyright © Cambridge University Press 2009

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