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53 Hoarding Behaviors are Associated with Greater Perceived Cognitive Dysfunction and Disability in Individuals with Late Life Depression

Published online by Cambridge University Press:  21 December 2023

Katie Firestone ,
John Bello ,
Divya Shridar ,
Michelle Kassel ,
Maria Kryza-Lacombe ,
Philip Insel ,
Kai Woodworth ,
Derek Satre ,
Craig Nelson  and
Carol Mathews
...Show all authors
Katie Firestone*
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
John Bello
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Divya Shridar
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Michelle Kassel
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Mental Illness Research, Education, and Clinical Centers, San Francisco VA Health Care System, San Francisco, CA, USA.
Maria Kryza-Lacombe
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Mental Illness Research, Education, and Clinical Centers, San Francisco VA Health Care System, San Francisco, CA, USA.
Philip Insel
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Kai Woodworth
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Derek Satre
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Division of Research, Kaiser Permanente Northern California, Oakland, CA, Oakland, CA, USA.
Craig Nelson
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Carol Mathews
Affiliation:
Department of Psychiatry, University of Florida, Gainesville, FL, Gainesville, FL, USA.
Duygu Tosun
Affiliation:
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Scott Mackin
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
*
Correspondence: Katie Firestone, UCSF (Katie.Firestone@ucsf.edu)
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Abstract

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Objective:

Perceived cognitive dysfunction is a common feature of late-life depression (LLD) that is associated with diminished quality of life and greater disability. Similar associations have been demonstrated in individuals with Hoarding Disorder. The degree to which hoarding behaviors (HB) are associated with greater perceived cognitive dysfunction and disability in individuals with concurrent LLD is not known.

Participants and Methods:

Participants with LLD (N=83) completed measures of hoarding symptom severity (Savings Inventory-Revised; SI-R) and were classified into two groups based on HB severity: LLD+HB who exhibited significant HB (SI-R . 41, n = 25) and LLD with low HB (SI-R < 41, n = 58). Additional measures assessed depression severity (Hamilton Depression Rating Scale; HDRS), perceived cognitive difficulties (Everyday Cognition Scale; ECOG), and disability (World Health Organization Disability Assessment Scale [WHODAS]-II-Short). Given a non-normal distribution of ECOG and WHODAS-II scores, non-parametric Wilcoxon-Mann-Whitney tests were used to assess group differences in perceived cognitive dysfunction and disability. A regression model assessed the extent to which perceived cognitive dysfunction was associated with hoarding symptom severity measured continuously, covarying for age, education, gender, and depression severity. A separate regression model assessed the extent to which disability scores were associated with perceived cognitive dysfunction and HB severity covarying for demographics and depression severity.

Results:

LLD+HB endorsed significantly greater perceived cognitive dysfunction (W = 1023, p = 0.003) and greater disability (W = 1006, p = < 0.001) compared to LLD. Regression models accounting for demographic characteristics and depression severity revealed that greater HB severity was associated with greater perceived cognitive dysfunction (β = 0.009, t = 2.765, p = 0.007). Increased disability was associated with greater perceived cognitive dysfunction (β = 4.792, t(71) = 3.551, p = 0.0007) and HB severity (β = 0.080, t(71) = 1.944, p = 0.056) approached significance after accounting for variance explained by depression severity and demographic covariates.

Conclusions:

Our results suggest that hoarding behaviors are associated with increased perceived cognitive dysfunction and greater disability in individuals with LLD. Screening for HB in individuals with LLD may help identify those at greater risk for poor cognitive and functional outcomes. Interventions that target HB and perceived cognitive difficulties may decrease risk for disability in LLD. However, longitudinal studies would be required to further evaluate these relationships.

Keywords

mood disordersself-report
Type
Poster Session 09: Psychiatric Disorders | Mood & Anxiety Disorders | Addiction | Social Cognition | Cognitive Neuroscience | Emotional and Social Processing
Information
Journal of the International Neuropsychological Society , Volume 29 , Supplement s1: Final Program Fifty First Annual Meeting International Neuropsychological Society February 1–4, 2023 San Diego, CA, USA , November 2023 , pp. 839
Copyright
Copyright © INS. Published by Cambridge University Press, 2023