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Memory Complaints with and without Memory Impairment: The Impact of Leukoaraiosis on Cognition

Published online by Cambridge University Press:  19 September 2011

Melissa Lamar ,
Thomas M. Dannhauser ,
Zuzana Walker ,
Joanne E. Rodda ,
Darren J. Cutinha  and
Sukhwinder S. Shergill
Melissa Lamar*
Affiliation:
Institute of Psychiatry, King's College London, London, United Kingdom
Thomas M. Dannhauser
Affiliation:
University College London, London, United Kingdom North Essex Partnership NHS Foundation Trust, Chelmsford, United Kingdom
Zuzana Walker
Affiliation:
University College London, London, United Kingdom North Essex Partnership NHS Foundation Trust, Chelmsford, United Kingdom
Joanne E. Rodda
Affiliation:
University College London, London, United Kingdom North Essex Partnership NHS Foundation Trust, Chelmsford, United Kingdom
Darren J. Cutinha
Affiliation:
University College London, London, United Kingdom North Essex Partnership NHS Foundation Trust, Chelmsford, United Kingdom
Sukhwinder S. Shergill
Affiliation:
Institute of Psychiatry, King's College London, London, United Kingdom
*
Correspondence and reprint requests to: Melissa Lamar, Department of Psychology, Institute of Psychiatry, King's College London, Box P077 De Crespigny Park, London SE5. E-mail: m.lamar@iop.kcl.ac.uk
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Abstract

White matter alterations, leukoaraiosis (LA) on structural MRI, are associated with cognitive deficits and increased risk of dementia. LA may also impact on subjective memory complaints in otherwise healthy older adults. Little is known about the interplay between LA memory complaints and cognition. We investigated cognitive phenotypes associated with LA in 42 non-demented older adults categorized as having subjective cognitive complaints with no objective cognitive impairment—the subjective cognitive impairment group (SCI; n = 12), amnesic mild cognitive impairment (aMCI; n = 20), or healthy controls (HC; n = 11). We measured LA severity on MRI with a 40-point visual rating scale. Controlling for age and Mini-Mental State Examination (MMSE) score, analyses revealed multiple between-group differences. Follow-up linear regression models investigating the underlying contributors to each clinic group's cognitive profile indicated that LA contributed to learning slope variance (after accounting for age and MMSE) but only for the SCI group. Although the SCI group showed a significantly steeper learning slope when compared to HC and aMCI, increasing LA severity negatively impacted this group's rate of learning. This, in conjunction with the significant contribution of age on SCI learning slope performance variance suggests that greater LA burden at a younger age may contribute to subtle changes in learning for individuals with subjective cognitive complaints. (JINS, 2011, 17, 1104–1112)

Keywords

Subjective cognitive impairmentMCIWhite matterLeukoaraiosisDementiaLearning and memory
Type
Regular Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 6 , November 2011 , pp. 1104 - 1112
Copyright
Copyright © The International Neuropsychological Society 2011

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