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Neurocognitive Profile of an Adult Sample With Chronic Kidney Disease

Published online by Cambridge University Press:  10 November 2010

Sofia Sánchez-Román ,
Feggy Ostrosky-Solís ,
Luis E. Morales-Buenrostro ,
M.G. Nogués-Vizcaíno ,
Josefina Alberú  and
Shawn M. McClintock
Sofia Sánchez-Román*
Affiliation:
National Autonomous University of Mexico, Mexico City, Mexico Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico
Feggy Ostrosky-Solís
Affiliation:
National Autonomous University of Mexico, Mexico City, Mexico
Luis E. Morales-Buenrostro
Affiliation:
Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico
M.G. Nogués-Vizcaíno
Affiliation:
Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico
Josefina Alberú
Affiliation:
Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico
Shawn M. McClintock
Affiliation:
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas Department of Psychiatry, New York State Psychiatric Institute/Columbia University, New York, New York
*
Correspondence and reprint requests to: Sofía Sánchez-Román, Departamento de Neurología y Psiquiatría, Vasco de Quiroga 15, Tlalpan, Sección XVI, 14000, México D.F. E-mail: sofiasan@yahoo.com
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Abstract

Chronic kidney disease (CKD) is a common and debilitating illness that impacts neurocognitive function. However, the majority of previous studies varied in methodologic design and rigor, thus minimizing definitive conclusions. The present study was designed to determine the impact of CKD on neurocognitive function through specific examination of CKD factors and therapeutic interventions. We evaluated 120 CKD outpatients and 41 healthy donors (controls) in terms of neurocognitive function, anxiety, and depressive symptomatology, and somnolence. Information regarding medical and treatment history was recorded. Twenty-three percent of CKD patients presented with cognitive impairment. Stage 5 patients had lower scores (p < .05) compared with controls and patients in stage 3 and 4 on measures of global cognitive function. No differences in global cognitive function were found between stage 3 and 4 patients and controls. A greater proportion of patients undergoing hemodialysis relative to those treated with peritoneal dialysis showed impairment on measures of memory functions. Results suggest that stage 5 CKD patients may present with impaired cognitive functions. Anemia appeared to be a key variable that may explain the memory impairment in this sample. Future longitudinal investigations of CKD are warranted to determine the trajectory of cognitive impairment. (JINS, 2010, 17, 000–000)

Keywords

Chronic kidney diseaseNeuropsychologyHemodialysisPeritoneal dialysisCognitive impairmentMemory
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 1 , January 2011 , pp. 80 - 90
Copyright
Copyright © The International Neuropsychological Society 2010

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