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Verbal learning and memory after childhood stroke

Published online by Cambridge University Press:  01 September 2004

AMY E. LANSING ,
JEFFREY E. MAX ,
DEAN C. DELIS ,
PETER T. FOX ,
JACK LANCASTER ,
FACUNDO F. MANES  and
AMY SCHATZ
AMY E. LANSING
Affiliation:
University of California, San Diego
JEFFREY E. MAX
Affiliation:
University of California, San Diego Children's Hospital and Health Center, San Diego
DEAN C. DELIS
Affiliation:
University of California, San Diego Veteran's Administration San Diego Healthcare Center
PETER T. FOX
Affiliation:
University of Texas Health Science Center, San Antonio
JACK LANCASTER
Affiliation:
University of Texas Health Science Center, San Antonio
FACUNDO F. MANES
Affiliation:
Raul Carrea Institute for Neurological Research–FLENI, Buenos Aires, Argentina
AMY SCHATZ
Affiliation:
University of California, San Diego
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Abstract

Verbal learning and memory (VLM) following pediatric stroke was characterized in a cross-sectional neuropsychological and neuroimaging study of 26 subjects, aged 5 to 17, with a history of pediatric stroke and 26 age, SES, and gender matched orthopedic controls. Further comparisons were made between the VLM profiles of stroke subjects with right versus left hemisphere lesions and early (≤12 months) versus late (>12 months) strokes. Overall, stroke subjects scored significantly lower than control subjects on several VLM indices (California Verbal Learning Test–Children; CVLT–C), as well as on measures of intellectual functioning (IQ) and auditory attention/working memory (Digit Span). Subgroup analyses of the stroke population found no significant differences in VLM, Digit Span, Verbal IQ or Performance IQ when left-hemisphere lesion subjects were compared to right-hemisphere lesion subjects. In contrast, early strokes were associated with significantly fewer words recalled after delay, reduced discriminability (fewer correct hits relative to false positive errors on recognition testing), and relatively worse auditory attention/working memory scores (Digit Span). These findings indicate that pediatric stroke subjects demonstrated more VLM impairment than control subjects, and early strokes were associated with greater recall and recognition deficits. In stark contrast with adult-onset stroke, both left- and right-hemisphere lesions during childhood resulted in similar VLM performance. (JINS, 2004, 10, 742–752.)

Keywords

Pediatric focal strokeVerbal learningMemoryCVLT
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 5 , September 2004 , pp. 742 - 752
Copyright
2004 The International Neuropsychological Society

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