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Working Memory and Intelligence Are Associated with Victoria Symptom Validity Test Hard Item Performance in Patients With Intractable Epilepsy

Published online by Cambridge University Press:  21 January 2013

Therese A. Keary ,
Thomas W. Frazier ,
Catherine J. Belzile ,
Jessica S. Chapin ,
Richard I. Naugle ,
Imad M. Najm  and
Robyn M. Busch
Therese A. Keary
Affiliation:
Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio Psychology Service, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio
Thomas W. Frazier
Affiliation:
Center for Pediatric Behavioral Health, Cleveland Clinic, Cleveland, Ohio
Catherine J. Belzile
Affiliation:
Department of Psychology, John Carroll University, University Heights, Ohio
Jessica S. Chapin
Affiliation:
Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio Epilepsy Center, Cleveland Clinic, Cleveland, Ohio
Richard I. Naugle
Affiliation:
Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio Epilepsy Center, Cleveland Clinic, Cleveland, Ohio
Imad M. Najm
Affiliation:
Epilepsy Center, Cleveland Clinic, Cleveland, Ohio
Robyn M. Busch*
Affiliation:
Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio Epilepsy Center, Cleveland Clinic, Cleveland, Ohio
*
Correspondence and reprint requests to: Robyn M. Busch, Cleveland Clinic Epilepsy Center, 9500 Euclid Avenue, P57, Cleveland, OH 44195. E-mail: buschr@ccf.org
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Abstract

Loring et al. (Journal of Clinical and Experimental Neuropsychology, 2005:27;610–617) observed relationships between VSVT hard item performance and IQ and memory indices in epilepsy surgical candidates, with a potential confound of low FSIQ on VSVT performance. The present study replicated the Loring et al. study in a larger sample and extended their findings by examining the relationships among VSVT performance, FSIQ, and working memory. A total of 404 patients with medically intractable epilepsy completed a comprehensive neuropsychological assessment. Differences in WAIS-III and WMS-III performance were examined as a function of VSVT hard score categories as determined by Grote et al. (2000)—that is, valid, >20/24; questionable, 18–20; or invalid, <18. Quantile regression models were constructed to compare the strength of the relationship between FSIQ and VSVT at various points of the FSIQ distribution. Linear regression analyses examined working memory as a potential mediator between FSIQ and VSVT performance. The invalid group performed more poorly than the valid and questionable groups on multiple measures of intelligence and memory. The strength of the relationship between FSIQ and VSVT hard item performance decreased as FSIQ increased, and working memory mediated this relationship. Results suggest VSVT hard item scores may be impacted by working memory difficulties and/or low intellectual functioning. (JINS, 2013, 19, 1–10)

Keywords

Symptom validityNeuropsychologyCognitionSeizuresIntelligenceWorking memory
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 3 , March 2013 , pp. 314 - 323
Copyright
Copyright © The International Neuropsychological Society 2013

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Footnotes

*

Current affiliation: Department of Psychology, John Carroll University, University Heights, Ohio.

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