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Age of disease onset influences cognition in Parkinson's disease

Published online by Cambridge University Press:  01 May 1998

HEATHER L. KATZEN ,
BONNIE E. LEVIN  and
MARIA L. LLABRE
HEATHER L. KATZEN
Affiliation:
Department of Psychology, University of Miami, Coral Gables, FL, USA
BONNIE E. LEVIN
Affiliation:
Department of Psychology, University of Miami, Coral Gables, FL, USA Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
MARIA L. LLABRE
Affiliation:
Department of Psychology, University of Miami, Coral Gables, FL, USA
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Abstract

It is controversial whether age of disease onset is related to cognitive decline in Parkinson's disease (PD). We administered 7 cognitive measures assessing visuospatial skills, memory, and executive functions to 222 patients with idiopathic PD and 108 normal control participants. Regression analyses demonstrated that older age of disease onset consistently predicted cognitive decline above and beyond normative aging and duration of illness. These findings suggest that older age of disease onset is a critical determinant of cognitive deterioration in PD. (JINS, 1998, 4, 285–290.)

Keywords

Parkinson's diseaseCognitionCognitive declineAge of onset
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 4 , Issue 3 , May 1998 , pp. 285 - 290
Copyright
© 1998 The International Neuropsychological Society

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