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Alcohol Consumption Does not Impede Recovery from Mild to Moderate Traumatic Brain Injury

Published online by Cambridge University Press:  18 August 2016

Noah D. Silverberg ,
William Panenka ,
Grant L. Iverson ,
Jeffrey R. Brubacher ,
Jason R. Shewchuk ,
Manraj K.S. Heran ,
Gary C.S. Oh ,
William G. Honer  and
Rael T. Lange
Noah D. Silverberg*
Affiliation:
Division of Physical Medicine & Rehabilitation, University of British Columbia, Vancouver, Canada Rehabilitation Research Program, GF Strong Rehab Centre, Vancouver, Canada Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts Red Sox Foundation and Massachusetts General Hospital Home Base Program, Boston, Massachusetts
William Panenka
Affiliation:
British Columbia Neuropsychiatry Program, University of British Columbia, Vancouver, Canada Department of Psychiatry, University of British Columbia, Vancouver, Canada
Grant L. Iverson
Affiliation:
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts Red Sox Foundation and Massachusetts General Hospital Home Base Program, Boston, Massachusetts Department of Psychiatry, University of British Columbia, Vancouver, Canada Spaulding Rehabilitation Hospital, Boston, Massachusetts
Jeffrey R. Brubacher
Affiliation:
Department of Emergency Medicine, University of British Columbia, Vancouver, Canada
Jason R. Shewchuk
Affiliation:
Department of Radiology, University of British Columbia, Vancouver, Canada
Manraj K.S. Heran
Affiliation:
Department of Radiology, University of British Columbia, Vancouver, Canada
Gary C.S. Oh
Affiliation:
Department of Radiology, University of British Columbia, Vancouver, Canada
William G. Honer
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Rael T. Lange
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada Defense and Veterans Brain Injury Center & National Intrepid Center of Excellence, Bethesda, Maryland Walter Reed National Military Medical Center, Bethesda, Maryland
*
Correspondence and reprint requests to: Noah D. Silverberg, Rehabilitation Research Program, GF Strong Rehab Centre, 4255 Laurel Street, Vancouver, British Columbia, V5Z 2G9, Canada. E-mail: noah.silverberg@vch.ca
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Abstract

Objectives: To examine the effect of pre-injury alcohol use, acute alcohol intoxication, and post-injury alcohol use on outcome from mild to moderate traumatic brain injury (TBI). Methods: Prospective inception cohort of patients who presented to the Emergency Department with mild to moderate TBI and had a blood alcohol level (BAL) taken for clinical purposes. Those who completed the 1-year outcome assessment were eligible for this study (N=91). Outcomes of interest were the count of post-concussion symptoms (British Columbia Post-Concussion Symptom Inventory), low neuropsychological test scores (Neuropsychological Assessment Battery), and abnormal regions of interest on diffusion tensor imaging (low fractional anisotropy). The main predictors were pre-injury alcohol consumption (Cognitive Lifetime Drinking History interview), BAL, and post-injury alcohol use. Results: The alcohol use variables were moderately to strongly inter-correlated. None of the alcohol use variables (whether continuous or categorical) were related to 1-year TBI outcomes in generalized linear modeling. Participants in this cohort generally had a good clinical outcome, regardless of their pre-, peri-, and post-injury alcohol use. Conclusions: Alcohol may not significantly alter long-term outcome from mild to moderate TBI. (JINS, 2016, 22, 816–827)

Keywords

Craniocerebral traumaPostconcussion symptomsNeuropsychological testsMagnetic resonance imagingDiffusion tensor imagingAlcohol drinkingAlcohol-related disorders
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 22 , Issue 8 , September 2016 , pp. 816 - 827
Copyright
Copyright © The International Neuropsychological Society 2016 

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