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Alerting Network Dysfunction in Early Multiple Sclerosis

Published online by Cambridge University Press:  24 May 2012

Lucía Crivelli ,
Mauricio F. Farez ,
Claudio D. González ,
Marcela Fiol ,
Alejandra Amengual ,
Ramón Leiguarda  and
Jorge Correale
Lucía Crivelli
Affiliation:
Department of Neurology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
Mauricio F. Farez*
Affiliation:
Department of Neurology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
Claudio D. González
Affiliation:
Department of Pharmacology, University of Buenos Aires School of Medicine. Argentina
Marcela Fiol
Affiliation:
Department of Neurology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
Alejandra Amengual
Affiliation:
Department of Neurology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
Ramón Leiguarda
Affiliation:
Department of Neurology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
Jorge Correale
Affiliation:
Department of Neurology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
*
Correspondence and reprint requests to: Mauricio F. Farez, Raúl Carrea Institute for Neurological Research, FLENI, Montañeses 2325, Buenos Aires (1428), Argentina. E-mail: rneuroinmunologia@fleni.org.ar
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Abstract

The objective of this study is to assess attention in recently diagnosed relapsing-remitting multiple sclerosis patients. Twenty-seven patients with early multiple sclerosis and low clinical disability scores (EDSS<2) and 27 sex-, age-, and education-matched healthy controls underwent attention assessment using the Attentional Network Test, a computerized task designed to measure efficiency independently in 3 attentional networks (Alerting, Orienting and Executive Control). MS patients had significantly less efficiency in the Alerting network (p = .006). In contrast, in the Orienting and Executive Control networks, they did not differ from controls. A significant interaction between Alerting and Executive Control was also found in the MS patients (p = .007). Early relapsing-remitting multiple sclerosis particularly affects the Alerting domain of attention, whereas the Orienting and Executive Control domains are not affected. (JINS, 2012, 18, 1–7)

Keywords

Multiple SclerosisAttentionAttentional network testExecutive functionCognitionNeuropsychology
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 4 , July 2012 , pp. 757 - 763
Copyright
Copyright © The International Neuropsychological Society 2012

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