Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-10T05:19:16.664Z Has data issue: false hasContentIssue false
  • English
  • Français

Body side of motor symptom onset in Parkinson's disease is associated with memory performance

Published online by Cambridge University Press:  08 September 2006

M.M. AMICK ,
J. GRACE  and
K.L. CHOU
M.M. AMICK
Affiliation:
Department of Medical Rehabilitation, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island
J. GRACE
Affiliation:
Department of Medical Rehabilitation, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island
K.L. CHOU
Affiliation:
Department of Clinical Neurosciences, Brown Medical School, Providence, Rhode Island NeuroHealth, Warwick, Rhode Island
Get access Rights & Permissions [Opens in a new window]

Abstract

The relation of body side of motor symptom onset in Parkinson's disease (PD) to memory measures associated with hemispheric dominance was examined. Fourteen patients with right body side motor symptom onset (RPD, inferred left hemisphere dysfunction) and 16 patients with left side onset (LPD, right hemisphere dysfunction) were administered measures of verbal (Hopkins Verbal Learning Test-Revised) and visual memory (Brief Visual Memory Test-Revised), that require similar task demands and are associated with left or right hemisphere dominance, respectively. The LPD group demonstrated poorer visual than verbal memory, both within group and in comparison to the RPD group. By contrast, the RPD group showed poorer verbal than visual memory within group. These findings suggest that side of motor symptom onset is associated with asymmetrical memory dysfunction (JINS, 2006, 12, 736–740.)

Keywords

LateralityDopamineLearningNeuropsychologyMovement disordersBasal ganglia
Type
BRIEF COMMUNICATIONS
Information
Journal of the International Neuropsychological Society , Volume 12 , Issue 5 , September 2006 , pp. 736 - 740
Copyright
© 2006 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Antonini, A., Vontobel, P., Psylla, M., Gunther, I., Maguire, P.R., Missimer, J., & Leenders, K.L. (1995). Complementary positron emission tomographic studies of the striatal dopaminergic system in Parkinson's disease. Archives of Neurology, 52, 1183–1190.Google Scholar
Benedict, H.B. (1997). Brief Visual Memory Test—Revised Professional Manual. Odessa, FL: Psychological Assessment Resources.
Blonder, L.X., Gur, R.E., Gur, R.C., Saykin, A.J., & Hurtig, H.I. (1989). Neuropsychological functioning in hemiparkinsonism. Brain and Cognition, 9, 244–257.Google Scholar
Bobholz, J.H. & Brandt, J. (1993). Assessment of cognitive impairment: Relationship of the Dementia Rating Scale to the Mini-Mental State Examination. Journal of Geriatric Psychiatry and Neurology, 6, 210–213.CrossRefGoogle Scholar
Brandt, J. & Benedict, H.B. (2001). Hopkins Verbal Learning Test—Revised Professional Manual. Odessa, FL: Psychological Assessment Resources.
Cronin-Golomb, A. & Amick, M.M. (2001). Spatial abilities in aging, Alzheimer's disease, and Parkinson's disease. In F. Boller & S. Cappa (Eds.), Aging and Dementia, 2 ed., Vol. 6 (pp. 119–144). Amsterdam: Elsevier.
Herzog, J., Volkmann, J., Krack, P., Kopper, F., Potter, M., Lorenz, D., Steinbach, M., Klebe, S., Hamel, W., Schrader, B., Weinert, D., Muller, D., Mehdorn, H.M., & Deuschl, G. (2003). Two-year follow-up of subthalamic deep brain stimulation in Parkinson's Disease. Movement Disorders, 18, 1332–37.Google Scholar
Innis, R.B., Seibyl, J.P., Scanley, B.E., Laruelle, M., Abi-Dargham, A., Wallace, E., Baldwin, R.M., Zea-Ponce, Y., Zoghbi, S., Wang, S., Gao, Y., Neumeyer, J.L., Charney, D.S., Hoffer, P.B., & Marek, K.L. (1993). Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. Proceedings of the National Academy of Science USA, 90, 11965–11969.Google Scholar
Jurica, P.J., Leitten, C.L., & Mattis, S. (2001). Dementia Rating Scale-2. Professional Manual. Lutz, FL: Psychological Assessment Resources.
Kempster, P.A., Gibb, W.R., Stern, G.M., & Lees, A.J. (1989). Asymmetry of substantia nigra neuronal loss in Parkinson's disease and its relevance to the mechanism of levodopa related motor fluctuations. Journal of Neurology, Neurosurgery, and Psychiatry, 52, 72–76.CrossRefGoogle Scholar
Lee, C.S., Schulzer, M., Mak, E., Hammerstad, J.P., Calne, S., & Calne, D.B. (1995). Patterns of asymmetry do not change over the course of idiopathic parkinsonism: Implications for pathogenesis. Neurology, 45, 199.Google Scholar
Middleton, F.A. & Strick, P.L. (2000a). Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Research/Brain Research Reviews, 31, 236–250.Google Scholar
Middleton, F.A. & Strick, P.L. (2000b). Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies. Brain Cognition, 42, 183–200.Google Scholar
Pillon, B., Boller, F., Levy, R., & Dubois, B. (2001). Cognitive Deficits and Dementia in Parkinson's disease. In F. Boller & S. Cappa (Ed.), Aging and Dementia, 2 ed., Vol. 6, (pp. 311–372). Amsterdam: Elsevier.
Postle, B.R., Jonides, J., Smith, E.E., Corkin, S., & Growdon, J.H. (1997). Spatial, but not object, delayed response is impaired in early Parkinson's disease. Neuropsychology, 11, 171–179.CrossRefGoogle Scholar
Starkstein, S., Leiguarda, R., Gershanik, O., & Berthier, M. (1987). Neuropsychological disturbances in hemiparkinson's disease. Neurology, 37, 1762–1764.Google Scholar
St. Clair, J., Borod, J.C., Sliwinski, M., Cote, L.J., & Stern, Y. (1998). Cognitive and affective functioning in Parkinson's disease patients with lateralized motor signs. Journal of Clinical and Experimental Neuropsychology, 20, 320–327.Google Scholar
Tomer, R., Levin, B.E., & Weiner, W.J. (1993). Side of onset of motor symptoms influences cognition in Parkinson's disease. Annals of Neurology, 34, 579–584.Google Scholar