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Categorical spatial memory in patients with mild cognitive impairment and Alzheimer dementia: Positional versus object-location recall

Published online by Cambridge University Press:  03 November 2009

ROY P.C. KESSELS ,
STEFAN RIJKEN ,
LIESBETH W.A. JOOSTEN-WEYN BANNINGH ,
NELLEKE VAN SCHUYLENBORGH-VAN ES  and
MARCEL G.M. OLDE RIKKERT
ROY P.C. KESSELS*
Affiliation:
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands Department of Medical Psychology, Radboud University Nijmegen Medical Centre, The Netherlands Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
STEFAN RIJKEN
Affiliation:
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands Private practice “Op ’t Veld”, Cuijk, The Netherlands
LIESBETH W.A. JOOSTEN-WEYN BANNINGH
Affiliation:
Department of Medical Psychology, Radboud University Nijmegen Medical Centre, The Netherlands Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
NELLEKE VAN SCHUYLENBORGH-VAN ES
Affiliation:
Department of Medical Psychology, Radboud University Nijmegen Medical Centre, The Netherlands Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
MARCEL G.M. OLDE RIKKERT
Affiliation:
Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
*
*Correspondence and reprint requests to: Roy Kessels, Radboud University Nijmegen Medical Centre, Department of Medical Psychology, Internal post 925 – Geriatrics, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: r.kessels@mps.umcn.nl
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Abstract

Memory for object locations, as part of spatial memory function, has rarely been studied in patients with Alzheimer dementia (AD), while studies in patients with Mild Cognitive Impairment (MCI) patients are lacking altogether. The present study examined categorical spatial memory function using the Location Learning Test (LLT) in MCI patients (n = 30), AD patients (n = 30), and healthy controls (n = 40). Two scoring methods were compared, aimed at disentangling positional recall (location irrespective of object identity) and object-location binding. The results showed that AD patients performed worse than the MCI patients on the LLT, both on recall of positional information and on recall of the locations of different objects. In addition, both measures could validly discriminate between AD and MCI patients. These findings are in agreement with the notion that visual cued-recall tests may have better diagnostic value than traditional (verbal) free-recall tests in the assessment of patients with suspected MCI or AD. (JINS, 2010, 16, 200–204.)

Keywords

Spatial memoryMild cognitive impairmentAlzheimer dementiaNeuropsychological assessmentObject-location memoryNonverbal memoryAmnesia
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 1 , January 2010 , pp. 200 - 204
Copyright
Copyright © The International Neuropsychological Society 2009

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References

REFERENCES

Adelstein, T.B., Kesner, K.P., & Strassberg, D.S. (1992). Spatial recognition and spatial order memory in patients with dementia of the Alzheimer’s type. Neuropsychologia, 30, 59–67.CrossRefGoogle ScholarPubMed
Brandt, J., Shpritz, B., Munro, C.A., Marsh, L., & Rosenblatt, A. (2005). Differential impairment of spatial location memory in Huntington’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 76, 1516–1519.CrossRefGoogle ScholarPubMed
Bucks, R.S., & Willison, J.R. (1997). Development and validation of the Location Learning Test (LLT): A test of visuo-spatial learning designed for use with older adults and dementia. Clinical Neuropsychologist, 11, 273–286.CrossRefGoogle Scholar
Bucks, R.S., Willison, J.R., & Byrne, L.M.T. (2000). Location learning test: Manual. Bury St. Edmunds, UK: Thames Valley Test Company.Google Scholar
Estévez-González, A., Kulisevsky, J., Boltes, A., Otermín, P., & García-Sánchez, C. (2003). Rey verbal learning test is a useful tool for differential diagnosis in the preclinical phase of Alzheimer’s disease: Comparison with mild cognitive impairment and normal aging. International Journal of Geriatric Psychiatry, 18, 1021–1028.CrossRefGoogle ScholarPubMed
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle ScholarPubMed
Hort, J., Laczó, J., Vyhnálek, M., Bojar, M., Bures, J., & Vlcek, K. (2007). Spatial navigation deficit in amnestic mild cognitive impairment. Proceedings of the National Academy of Sciences of the United States of America, 104, 4042–4047.Google Scholar
Ivanoiu, A., Adam, S., Van der Linden, M., Salmon, E., Juillerat, A.C., Mulligan, R., et al. (2005). Memory evaluation with a new cued recall test in patients with mild cognitive impairment and Alzheimer’s disease. Journal of Neurology, 252, 47–55.CrossRefGoogle ScholarPubMed
Kessels, R.P.C., Hendriks, M.P.H., Schouten, J., Van Asselen, M., & Postma, A. (2004). Spatial memory deficits in patients after unilateral amygdalohippocampectomy. Journal of the International Neuropsychological Society, 10, 907–912.CrossRefGoogle Scholar
Kessels, R.P.C., Nys, G.M.S., Brands, A.M.A., Van den Berg, E., & Van Zandvoort, M.J.E. (2006). The modified Location Learning Test: Norms for the assessment of spatial memory function in neuropsychological patients. Archives of Clinical Neuropsychology, 21, 841–846.Google Scholar
Kessels, R.P.C., Postma, A., & De Haan, E.H.F. (1999). Object relocation: A program for setting up, running, and analyzing experiments on memory for object locations. Behavior Research Methods, Instruments, & Computers, 31, 423–428.CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed
Milner, B., Johnsrude, I., & Crane, J. (1997). Right medial temporal-lobe contribution to object-location memory. Philosophical Transactions of the Royal Society of London. 352B, 1469–1474.Google Scholar
Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183–194.CrossRefGoogle ScholarPubMed
Piekema, C., Kessels, R.P.C., Mars, R.B., Petersson, K.M., & Fernández, G. (2006). The right hippocampus participates in short-term memory maintenance of object-location associations. Neuroimage, 33, 374–382.CrossRefGoogle ScholarPubMed
Postma, A., Kessels, R.P.C., & Van Asselen, M. (2008). How the brain remembers and forgets where things are: The neurocognition of object location memory. Neuroscience and Biobehavioral Reviews, 32, 1339–1345.CrossRefGoogle ScholarPubMed
Schmand, B., Lindeboom, J., & Van Harskamp, F. (1992). Nederlandse Leestest voor Volwassenen [Dutch Adult Reading Test]. Lisse, The Netherlands: Swets & Zeitlinger.Google Scholar
Tepest, R., Wang, L., Csernansky, J.G., Neubert, P., Heun, R., Scheef, L., et al. (2008). Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer’s dementia. Dementia and Geriatric Cognitive Disorders, 26, 323–329.CrossRefGoogle ScholarPubMed
Van Asselen, M., Kessels, R.P.C., Kappelle, L.J., & Postma, A. (2008). Categorical and coordinate spatial representations within object-location memory. Cortex, 44, 249–256.Google Scholar
Van der Elst, W., Van Boxtel, M.P., Van Breukelen, G.J., & Jolles, J. (2005). Rey’s Verbal Learning Test: Normative data for 1855 healthy participants aged 24–81 years and the influence of age, sex, education, and mode of presentation. Journal of the International Neuropsychological Society, 11, 290–302.CrossRefGoogle ScholarPubMed