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Cerebral blood flow velocity and language functioning in pediatric sickle cell disease

Published online by Cambridge University Press:  03 February 2010

CARMEN E. SANCHEZ ,
JEFFREY SCHATZ  and
CARLA W. ROBERTS
CARMEN E. SANCHEZ*
Affiliation:
Department of Psychology, University of South Carolina, Columbia, South Carolina
JEFFREY SCHATZ
Affiliation:
Department of Psychology, University of South Carolina, Columbia, South Carolina
CARLA W. ROBERTS
Affiliation:
Department of Pediatrics, University of South Carolina, Columbia, South Carolina
*
*Correspondence and reprint requests to: Carmen E. Sanchez, Department of Psychology, University of South Carolina, Columbia, SC, 29208. E-mail: sanchece@mailbox.sc.edu
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Abstract

We investigated the association of increased cerebral blood flow velocity with specific language abilities in children with sickle cell disease (SCD). Thirty-nine children ages 5 to 8 years old with high-risk genotypes of SCD underwent cognitive testing, which included tests of language skills, visual motor skills, and attention/working memory as part of a routine hematology health-maintenance visit. Transcranial Doppler (TCD) velocities were obtained from review of medical records, with the velocities that were in closest temporal proximity to the cognitive assessment used in the analysis. TCD velocities predicted scores on tests of syntactical skills, even when controlling for anemia severity. Semantic and phonological ability and other cognitive skills were not strongly related to TCD velocities. Elevated blood flow velocities in children with high-risk SCD may contribute to a specific language impairment or to a broader dysfunction of short-term and/or working memory. This study underscores the need for clinicians to monitor language skills of children with SCD who have elevated TCD velocities, as these cognitive abilities might be particularly sensitive to cerebrovascular disruption related to their disease. (JINS, 2010, 16, 326–334.)

Keywords

AnemiaSickle CellNeurobehavioral manifestationsChildUltrasonographyDopplerTranscranialCerebrovascular disordersNeuropsychological test
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 2 , March 2010 , pp. 326 - 334
Copyright
Copyright © The International Neuropsychological Society 2010

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