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Cognitive and Functional Outcome After Out of Hospital Cardiac Arrest

Published online by Cambridge University Press:  04 January 2011

Michael P. Alexander ,
Ginette Lafleche ,
David Schnyer ,
Chun Lim  and
Mieke Verfaellie
Michael P. Alexander*
Affiliation:
Cognitive Neurology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Rotman Research Institute, Baycrest Hospital, Toronto, Ontario, Canada
Ginette Lafleche
Affiliation:
Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts
David Schnyer
Affiliation:
Department of Psychology, University of Texas, Austin, Texas
Chun Lim
Affiliation:
Cognitive Neurology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
Mieke Verfaellie
Affiliation:
Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts
*
Correspondence and reprint requests to: Michael P. Alexander, MD, Cognitive Neurology Unit, KS 253, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. E-mail: malexand@bidmc.harvard.edu
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Abstract

The nature of residual cognitive deficits after out of hospital cardiac arrest (OHCA) is incompletely described and has never been defined against a cardiac control (CC) group. The objective of this study is to examine neuropsychological outcomes 3 months after OHCA in patients in a “middle range” of acute severity. Thirty prospective OHCA admissions with coma >1 day and responsive but confused at 1 week, and 30 non-OHCA coronary care admissions were administered standard tests in five cognitive domains. OHCA subjects fell into two deficit profiles. One group (N = 20) had mild memory deficits and borderline psychomotor deficits compared to the CC group; 40% had returned to work. The other group (N = 10) had severe impairments in all domains. Coma duration was associated with group. Neither group had a high prevalence of depression. For most patients within the “middle range” of acute severity of OHCA, cognitive and functional outcomes at 3 months were encouraging. (JINS, 2011, 17, 364–368)

Keywords

Hypoxia–ischemiaBrainAmnesiaExecutive functionsPsychomotorVentricular fibrillationRecovery of function
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 2 , 28 February 2011 , pp. 364 - 368
Copyright
Copyright © The International Neuropsychological Society 2010

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