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Cognitive Dysfunction after Chemotherapy For Breast Cancer

Published online by Cambridge University Press:  24 March 2014

Kim Edelstein  and
Lori J. Bernstein
Kim Edelstein*
Affiliation:
Psychosocial Oncology and Palliative Care, Princess Margaret Cancer Centre, Department of Psychiatry, University of Toronto, Toronto, Canada
Lori J. Bernstein
Affiliation:
Psychosocial Oncology and Palliative Care, Princess Margaret Cancer Centre, Department of Psychiatry, University of Toronto, Toronto, Canada
*
Correspondence and reprint requests to: Kim Edelstein, Pencer Brain Tumor Centre, Princess Margaret Cancer Centre, 610 University Ave, 18-716, Toronto Canada M5G 2M9. E-mail: kim.edelstein@uhn.ca
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Abstract

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Type
Symposia
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 4 , April 2014 , pp. 351 - 356
Copyright
Copyright © The International Neuropsychological Society 2014 

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References

Ahles, T.A., Root, J.C., Ryan, E.L. (2012). Cancer- and cancer treatment-associated cognitive change: An update on the state of the science. Journal of Clinical Oncology, 30, 3675–3686.Google Scholar
Ahles, T.A., Saykin, A.J. (2007). Candidate mechanisms for chemotherapy-induced cognitive changes. Nature Reviews Cancer, 7, 192–201.Google Scholar
Ahles, T.A., Saykin, A.J. (2001). Cognitive effects of standard-dose chemotherapy in patients with cancer. Cancer Investigations, 19, 812–820.Google Scholar
Ahles, T.A., Saykin, A.J., McDonald, B.C., Furstenberg, C.T., Cole, B.F., Hanscom, B.S., Kaufman, P.A. (2008). Cognitive function in breast cancer patients prior to adjuvant treatment. Breast Cancer Research and Treatment, 110, 143–152.CrossRefGoogle ScholarPubMed
Ahles, T.A., Saykin, A.J., McDonald, B.C., Li, Y., Furstenberg, C.T., Hanscom, B.S., Kaufman, P.A. (2010). Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: Impact of age and cognitive reserve. Journal of Clinical Oncology, 28, 4434–4440.CrossRefGoogle ScholarPubMed
Anderson-Hanley, C., Sherman, M.L., Riggs, R., Agocha, V.B., Compas, B.E. (2003). Neuropsychological effects of treatments for adults with cancer: A meta-analysis and review of the literature. Journal of the International Neuropsychological Society, 9, 967–982.CrossRefGoogle Scholar
Bender, C.M., Pacella, M.L., Sereika, S.M., Brufsky, A.M., Vogel, V.G., Rastogi, P., Casillo, F.E., Ryan, C.M. (2008). What do perceived cognitive problems reflect? Journal of Supportive Oncology, 6, 238–242.Google Scholar
Bender, C.M., Sereika, S.M., Brufsky, A.M., Ryan, C.M., Vogel, V.G., Rastogi, P., Berga, S.L. (2007). Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancer. Menopause, 14, 995–998.Google Scholar
Bläsi, S., Zehnder, A.E., Berres, M., Taylor, K.I., Spiegel, R., Monsch, A.U. (2009). Norms for change in episodic memory as a prerequisite for the diagnosis of mild cognitive impairment (MCI). Neuropsychology, 23, 189–200.Google Scholar
Boykoff, N., Moieni, M., Subramanian, S.K. (2009). Confronting chemobrain: An in-depth look at survivors’ reports of impact on work, social networks, and health care response. Journal of Cancer Survivorship, 3, 223–232.Google Scholar
Brouwers, P., Riccardi, R., Fedio, P., Poplack, D.G. (1985). Long-term neuropsychologic sequelae of childhood leukemia: Correlation of CT scan brain abnormalities. Journal of Pediatrics, 106, 723–728.Google Scholar
Castellon, S.A., Ganz, P.A., Bower, J.E., Petersen, L., Abraham, L., Greendale, G.A. (2004). Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen. Journal of Clinical Experimental Neuropsychology, 26, 955–969.Google Scholar
Chelune, G.J., Naugle, R.I., Lüders, H., Sedlak, J., Awad, I.A. (1993). Individual change after epilepsy surgery: Practice effects and base-rate information. Neuropsychology, 7, 41–52.Google Scholar
Children's Oncology Group. (2008). Long-term follow-up guidelines for survivors of childhood, adolescent and young adult cancers, Version 3.0. Arcadia, CA: Children's Oncology Group; www.survivorshipguidelines.org.Google Scholar
Cimprich, B., Reuter-Lorenz, P., Nelson, J., Clark, P.M., Therrien, B., Normolle, D., Welsh, R.C. (2010). Prechemotherapy alterations in brain function in women with breast cancer. Journal of Clinical and Experimental Neuropsychology, 32, 324–331.Google Scholar
Cimprich, B., So, H., Ronis, D.L., Trask, C. (2005). Pre-treatment factors related to cognitive functioning in women newly diagnosed with breast cancer. Psychooncology, 14, 70–78.Google Scholar
Coates, A., Abraham, S., Kaye, S.B., Sowerbutts, T., Frewin, C., Fox, R.M., Tattersall, M.H. (1983). On the receiving end--patient perception of the side-effects of cancer chemotherapy. European Journal of Cancer and Clinical Oncology, 19, 203–208.Google Scholar
Collins, B., Mackenzie, J., Kyeremanteng, C. (2013). Study of the cognitive effects of chemotherapy: Considerations in selection of a control group. Journal of Clinical and Experimental Neuropsychology, 35, 435–444.Google Scholar
Collins, B., Mackenzie, J., Stewart, A., Bielajew, C., Verma, S. (2009). Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment. Psychooncology, 18, 134–143.Google Scholar
Collins, B., Mackenzie, J., Tasca, G.A., Scherling, C., Smith, A. (2012). Cognitive effects of chemotherapy in breast cancer patients: A dose-response study. Psychooncology, 22, 1517–1527.Google Scholar
Correa, D.D., Ahles, T.A. (2008). Neurocognitive changes in cancer survivors. Cancer, 14, 396–400.Google Scholar
Dennis, M., Yeates, K.O., Taylor, H.G., Fletcher, J.M. (2007). Brain reserve capacity, cognitive reserve capacity, and age-based functional plasticity after congenital and acquired brain injury in children. In: Y. Stern (Ed.), Cognitive reserve, theory and applications. New York: Taylor and Francis.Google Scholar
de Ruiter, M.B., Reneman, L., Boogerd, W., Veltman, D.J., van Dam, F.S., Nederveen, A.J., Schagen, S.B. (2011). Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Human Brain Mapping, 32, 1206–1219.Google Scholar
Deprez, S., Amant, F., Smeets, A., Peeters, R., Leemans, A., Van Hecke, W., Sunaert, S. (2012). Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning. Journal of Clinical Oncology, 30, 274–281.CrossRefGoogle ScholarPubMed
Edelstein, K., D'Agostino, N., Bernstein, L.J., Nathan, P.C., Greenberg, M.L., Hodgson, D.C., Spiegler, B.J. (2011). Long-term neurocognitive outcomes in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Pediatric Hematology Oncology, 33, 450–458.Google Scholar
Ferguson, R.J., McDonald, B.C., Saykin, A.J., Ahles, T.A. (2007). Brain structure and function differences in monozygotic twins: Possible effects of breast cancer chemotherapy. Journal of Clinical Oncology, 25, 3866–3870.Google Scholar
Gan, H.K., Bernstein, L.J., Brown, J., Ringash, J., Vakilha, M., Wang, L., Siu, L.L. (2011). Cognitive functioning after radiotherapy or chemoradiotherapy for head-and-neck cancer. International Journal of Radiation Oncology and Biological Physics, 81, 126–134.CrossRefGoogle ScholarPubMed
Greer, S., Silberfarb, P.M. (1982). Psychological concomitants of cancer: Current state of research. Psychological Medicine, 12, 563–573.Google Scholar
Hermelink, K., Untch, M., Lux, M.P., Kreienberg, R., Beck, T., Bauerfeind, I., Münzel, K. (2007). Cognitive function during neoadjuvant chemotherapy for breast cancer: Results of a prospective, multicenter, longitudinal study. Cancer, 109, 1905–1913.CrossRefGoogle ScholarPubMed
Hurria, A., Rosen, C., Hudis, C., Zuckerman, E., Panageas, K.S., Lachs, M.S., Holland, J. (2006). Cognitive function of older patients receiving adjuvant chemotherapy for breast cancer: A pilot prospective longitudinal study. Journal of the American Geriatric Society, 54, 925–931.Google Scholar
Inagaki, M., Yoshikawa, E., Matsuoka, Y., Sugawara, Y., Nakano, T., Akechi, T., Uchitomi, Y. (2007). Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer, 109, 146–156.Google Scholar
Iverson, G.L. (2001). Interpreting change on the WAIS–III/WMS–III in clinical samples. Archives of Clinical Neuropsychology, 16, 183–191.Google Scholar
Jacobson, N.S., Truax, P. (1991). Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology, 59, 12–19.Google Scholar
Jansen, C.E., Miaskowski, C.A., Dodd, M.J., Dowling, G.A. (2007). A meta-analysis of the sensitivity of various neuropsychological tests used to detect chemotherapy-induced cognitive impairment in patients with breast cancer. Oncology Nursing Forum, 34, 997–1005.Google Scholar
Jenkins, V., Shilling, V., Deutsch, G., Bloomfield, D., Morris, R., Allan, S., Winstanley, J. (2006). A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer. British Journal of Cancer, 94, 828–834.Google Scholar
Jim, H.S.L., Phillips, K.M., Chait, S., Faul, L.A., Popa, M.A., Lee, Y.-H., Small, B.J. (2012). Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. Journal of Clinical Oncology, 30, 3578–3587.Google Scholar
Kadan-Lottick, N.S., Zeltzer, L.K., Liu, Q., Yasui, Y., Ellenberg, L., Gioia, G., Krull, K.R. (2010). Neurocognitive functioning in adult survivors of childhood non-central nervous system cancers. Journal of the National Cancer Institute, 102, 881–893.Google Scholar
Kenzik, K.M., Huang, I.C., Brinkman, T.M., Shenkman, E.A., Robison, L.L., Hudson, M.M., Krull, K.R. (2012). Item response analysis and concurrent validity of the childhood cancer survivor study-neurocognitive questionnaire: A report from the St. Jude Lifetime Cohort (SJLIFE). Manuscript presented at the 12th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer. Williamsburg, VA, June 2012.Google Scholar
Kesler, S.R., Wefel, J.S., Hosseini, S.M., Cheung, M., Watson, C.L., Hoeft, F. (2013). Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls. Proceedings of the National Academy of Sciences of the United States of America, 110, 11600–11605.CrossRefGoogle ScholarPubMed
Koppelmans, V., Breteler, M.M., Boogerd, W., Seynaeve, C., Gundy, C., Schagen, S.B. (2012). Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. Journal of Clinical Oncology, 30, 1080–1086.Google Scholar
Krull, K.R., Sabin, N.D., Reddick, W.E., Zhu, L., Armstrong, G.T., Green, D.M., Hudson, M.M. (2012). Neurocognitive function and CNS integrity in adult survivors of childhood Hodgkin lymphoma. Journal of Clinical Oncology, 30, 3618–3624.Google Scholar
Levine, P.M., Silberfarb, P.M., Lipowski, Z.J. (1978). Mental disorders in cancer patients: A study of 100 psychiatric referrals. Cancer, 42, 1385–1391.Google Scholar
MacCormick, R.E. (2006). Possible acceleration of aging by adjuvant chemotherapy: A cause of early onset frailty? Medical Hypotheses, 67, 212–215.Google Scholar
McDonald, B.C., Conroy, S.K., Ahles, T.A., West, J.D., Saykin, A.J. (2012). Alterations in brain activation during working memory processing associated with breast cancer and treatment: A prospective functional magnetic resonance imaging study. Journal of Clinical Oncology, 30, 2500–2508.CrossRefGoogle ScholarPubMed
McSweeny, A.J., Naugle, R.I., Chelune, G.J., Lüders, H. (1993). T scores for change: An illustration of a regression approach to depicting change in clinical neuropsychology. The Clinical Neuropsychologist, 7, 300–312.Google Scholar
Munir, F., Burrows, J., Yarker, J., Kalawsky, K., Bains, M. (2010). Women's perceptions of chemotherapy-induced cognitive side affects on work ability: A focus group study. Journal of Clinical Nursing, 19, 1362–1370.Google Scholar
National Cancer Institute (2012). Cancer trends progress report – 2011/2012 update. Bethesda, MD: NIH, DHHS http://progressreport.cancer.gov.Google Scholar
Nguyen, C.M., Yamada, T.H., Beglinger, L.J., Cavanaugh, J.E., Denburg, N.I., Schultz, S.K. (2013). Cognitive features 10 or more years after successful breast cancer survival: Comparisons across types of cancer interventions. Psychooncology, 22, 862–868.CrossRefGoogle ScholarPubMed
Oberst, K., Bradley, C.J., Gardiner, J.C., Schenk, M., Given, C.W. (2010). Work task disability in employed breast and prostate cancer patients. Journal of Cancer Survivorship, 4, 322–330.CrossRefGoogle ScholarPubMed
Oxman, T.E., Silberfarb, P.M. (1980). Serial cognitive testing in cancer patients receiving chemotherapy. American Journal of Psychiatry, 137, 1263–1265.Google Scholar
Paganini-Hill, A., Clark, L.J. (2000). Preliminary assessment of cognitive function in breast cancer patients treated with tamoxifen. Breast Cancer Research and Treatment, 64, 165–176.CrossRefGoogle ScholarPubMed
Parsons, H.M., Harlan, L.C., Lynch, C.F., Hamilton, A.S., Wu, X.C., Kato, I., Keegan, T.H. (2012). Impact of cancer on work and education among adolescent and young adult cancer survivors. Journal of Clinical Oncology, 30, 2393–2400.Google Scholar
Pullens, M.J., De Vries, J., Roukema, J.A. (2010). Subjective cognitive dysfunction in breast cancer patients: A systematic review. Psychooncology, 19, 1127–1138.Google Scholar
Rugo, H.S., Ahles, T. (2003). The impact of adjuvant therapy for breast cancer on cognitive function: Current evidence and directions for research. Seminars in Oncology, 30, 749–762.Google Scholar
Saykin, A.J., de Ruiter, M.B., McDonald, B.C., Deprez, S., Silverman, D.H. (2013). Neuroimaging biomarkers and cognitive function in non-CNS cancer and its treatment: Current status and recommendations for future research. Brain Imaging Behavior, 7, 363–373.Google Scholar
Scarmeas, N., Stern, Y. (2003). Cognitive reserve and lifestyle. Journal of Clinical and Experimental Neuropsychology, 25, 625–633.CrossRefGoogle ScholarPubMed
Schagen, S.B., Muller, M.J., Boogerd, W., Mellenbergh, G.J., van Dam, F.S. (2006). Change in cognitive function after chemotherapy: A prospective longitudinal study in breast cancer patients. Journal of the National Cancer Institute, 98, 1742–1745.Google Scholar
Schagen, S.B., Muller, M.J., Boogerd, W., Rosenbrand, R.M., van Rhijn, D., Rodenhuis, S., van Dam, F.S. (2002). Late effects of adjuvant chemotherapy on cognitive function: A follow-up study in breast cancer patients. Annals of Oncology, 13, 1387–1397.Google Scholar
Schilder, C.M., Seynaeve, S., Beex, L.V., Boogerd, W., Linn, S.C., Gundy, C.M., Schagen, S.B. (2010). Effects of Tamoxifen and Exemestane on cognitive functioning of postmenopausal patients with breast cancer: Results from the neuropsychological side study of the Tamoxifen and Exemestane Adjuvant Multinational Trial. Journal of Clinical Oncology, 28, 1294–1300.CrossRefGoogle ScholarPubMed
Seruga, B., Zhang, H., Bernstein, L.J., Tannock, I.F. (2008). Cytokines and their relationship to the symptoms and outcome of cancer. Nature Reviews Cancer, 8, 887–899.Google Scholar
Silberfarb, P.M. (1983). Chemotherapy and cognitive defects in cancer patients. Annual Review of Medicine, 34, 35–46.Google Scholar
Silverman, D.H., Dy, C.J., Castellon, S.A., Lai, J., Pio, B.S., Abraham, L., Ganz, P.A. (2007). Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy. Breast Cancer Research and Treatment, 103, 303–311.CrossRefGoogle ScholarPubMed
Simó, M., Rifà-Ros, X., Rodriguez-Fornells, A., Bruna, J. (2013). Chemobrain: A systematic review of structural and functional neuroimaging studies. Neuroscience and Biobehavioral Reviews, 37, 1311–1321.Google Scholar
Stern, Y. (2006). Cognitive reserve and Alzheimer disease. Alzheimer Disease and Associated Disorders, 20, 112–117.Google Scholar
Stewart, A., Bielajew, C., Collins, B., Parkinson, M., Tomiak, E. (2006). A meta-analysis of the neuropsychological effects of adjuvant chemotherapy treatment in women treated for breast cancer. The Clinical Neuropsychologist, 20, 76–89.CrossRefGoogle ScholarPubMed
Tannock, I.F., Ahles, T.A., Ganz, P.A., Van Dam, F.S. (2004). Cognitive impairment associated with chemotherapy for cancer: Report of a workshop. Journal of Clinical Oncology, 22, 2233–2239.CrossRefGoogle ScholarPubMed
van Dam, F.S., Schagen, S.B., Muller, M.J., Boogerd, W., v.d. Wall, E., Droogleever Fortuyn, M.E., Rodenhuis, S. (1998). Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: High-dose versus standard-dose chemotherapy. Journal of the National Cancer Institute, 90, 210–218.Google Scholar
Vardy, J.L., Dhillon, H.M., Pond, G.R., Rourke, S., Xu, W., Renton, C., Tannock, I. (2012). Cognitive function and fatigue in colorectal cancer (CRC) patients: A prospective longitudinal controlled study. Journal of Clinical Oncology, 30(Suppl), 9021.Google Scholar
Vardy, J., Tannock, I. (2007). Cognitive function after chemotherapy in adults with solid tumours. Critical Reviews in Oncology and Hematology, 63, 183–202.Google Scholar
Vardy, J., Wong, K., Yi, Q.L., Park, A., Maruff, P., Wagner, L., Tannock, I.F. (2006). Assessing cognitive function in cancer patients. Supportive Care in Cancer, 14, 1111–1118.CrossRefGoogle ScholarPubMed
Wefel, J.S., Saleeba, A.K., Buzdar, A.U., Meyers, C.A. (2010). Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer, 116, 3348–3356.Google Scholar
Wefel, J.S., Schagen, S.B. (2012). Chemotherapy-related cognitive dysfunction. Current Neurology and Neuroscience Reports, 12, 267–275.Google Scholar
Wefel, J.S., Vardy, J., Ahles, T., Schagen, S.B. (2011). International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. The Lancet Oncology, 12, 703–708.Google Scholar
Wefel, J.S., Vidrine, D.J., Veramonti, T.L., Meyers, C.A., Marani, S.K., Hoekstra, H.J., Gritz, E.R. (2011). Cognitive impairment in men with testicular cancer prior to adjuvant therapy. Cancer, 117, 190–196.Google Scholar
Wieneke, M.H., Dienst, E.R. (1995). Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer. Psychooncology, 4, 61–66.Google Scholar