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Deep versus Periventricular White Matter Lesions and Cognitive Function in a Community Sample of Middle-Aged Participants

Published online by Cambridge University Press:  12 June 2012

Juan José Soriano-Raya ,
Júlia Miralbell ,
Elena López-Cancio ,
Núria Bargalló ,
Juan Francisco Arenillas ,
Maite Barrios ,
Cynthia Cáceres ,
Pere Toran ,
Maite Alzamora  and
Antoni Dávalos
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Juan José Soriano-Raya
Affiliation:
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
Júlia Miralbell
Affiliation:
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
Elena López-Cancio
Affiliation:
Stroke Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Badalona, Barcelona, Spain
Núria Bargalló
Affiliation:
Radiology Department, Image Diagnosis Center, Hospital Clinic, Barcelona, Spain August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
Juan Francisco Arenillas
Affiliation:
Stroke Unit, Department of Neurology, Hospital Clínico Universitario, Valladolid, Spain
Maite Barrios
Affiliation:
Department of Methodology of Behavioral Sciences, University of Barcelona, Barcelona, Spain
Cynthia Cáceres
Affiliation:
Stroke Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Badalona, Barcelona, Spain
Pere Toran
Affiliation:
Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Mataró, Barcelona, Spain Primary Healthcare Centre Gatassa, Mataró, Barcelona, Spain
Maite Alzamora
Affiliation:
Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Mataró, Barcelona, Spain Primary Healthcare Centre Riu Nord-Riu Sud, Santa Coloma de Gramenet, Barcelona, Spain
Antoni Dávalos
Affiliation:
Stroke Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Badalona, Barcelona, Spain
Maria Mataró*
Affiliation:
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Spain
*
Correspondence and reprint requests to: Maria Mataró, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron 171, 08035 Barcelona, Spain. E-mail: mmataro@ub.edu
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Abstract

The association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12)

Keywords

LeukoencephalopathiesMRINeuropsychologyCognition disordersExecutive functionVisuospatial skills
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 5 , September 2012 , pp. 874 - 885
Copyright
Copyright © The International Neuropsychological Society 2012

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