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The Effects of Age and HIV on Neuropsychological Performance

Published online by Cambridge University Press:  10 December 2010

Victor Valcour ,
Robert Paul ,
John Neuhaus  and
Cecilia Shikuma
Victor Valcour*
Affiliation:
Memory and Aging Center, Department of Neurology and Division of Geriatric Medicine/Department of Medicine, University of California at San Francisco, San Francisco, California Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii Department of Geriatric Medicine, University of Hawaii-Manoa, Honolulu, Hawaii
Robert Paul
Affiliation:
Department of Psychology, Behavioral Neuroscience, University of Missouri – St. Louis, St. Louis, Missouri
John Neuhaus
Affiliation:
Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California
Cecilia Shikuma
Affiliation:
Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
*
Correspondence and reprint requests to: Victor Valcour, MD, Memory and Aging Center, Suite 905, 350 Parnassus Avenue, San Francisco, CA 94143. E-mail: vvalcour@memory.ucsf.edu
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Abstract

Both HIV and aging impact performance on neuropsychological testing; however, evidence for differences between HIV effects in younger compared to older subjects (interaction effects) is limited and the findings have been inconsistent. Coexisting morbidities that contribute to cognitive impairment in HIV include those not directly referable to infection, per se, and are more prevalent with advancing age, increasing the likelihood that HIV and age effects may be largely independent. As individuals survive with HIV into geriatric age groups, greater clarity on these relationships is essential. We present cross-sectional data from a large (n = 450) cohort designed to analyze HIV, age, and interaction effects using a well-matched cohort of HIV-negative individuals. Results reveal limited evidence for interaction effects between HIV and age on neuropsychological performance. We conclude that older age does not significantly influence neuropsychological performance among HIV patients when seronegative controls are largely composed of individuals from a similar socioeconomic background. (JINS, 2011, 17, 1–6)

Keywords

HIVAIDS dementia complexNeuropsychological testsAgingAcquired immunodeficiency syndromeCognition disorders
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 1 , January 2011 , pp. 190 - 195
Copyright
Copyright © The International Neuropsychological Society 2010

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