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The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive Profile

Published online by Cambridge University Press:  06 January 2017

Claire Lancaster ,
Naji Tabet  and
Jennifer Rusted
Claire Lancaster
Affiliation:
School of Psychology, University of Sussex, Brighton, East Sussex
Naji Tabet
Affiliation:
Brighton and Sussex Medical School, Institute of Postgraduate Medicine, Brighton, East Sussex
Jennifer Rusted*
Affiliation:
School of Psychology, University of Sussex, Brighton, East Sussex
*
Correspondence and reprint requests to: Jennifer Rusted, School of Psychology, University of Sussex, Brighton, East Sussex, BN1 9QG. E-mail: j.rusted@sussex.ac.uk
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Abstract

Objectives: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences in cognition in mid-adulthood, when detrimental effects of the allele may first be detectable. Methods: Thirty-six papers investigating the behavioral effects of APOE ε4 in mid-adulthood (defined as a mean sample age between 35 and 60 years) were reviewed. In addition, the effect of carrying an ε4 allele on individual cognitive domains was assessed in separate meta-analyses. Results: The average effect size of APOE ε4 status was non-significant across cognitive domains. Further consideration of genotype effects indicates preclinical effects of APOE ε4 may be observable in memory and executive functioning. Conclusions: The cognitive profile of APOE ε4 carriers at mid-age remains elusive. Although there is support for comparable performance by ε4 and non-e4 carriers in the 5th decade, studies administering sensitive cognitive paradigms indicate a more nuanced profile of cognitive differences. Methodological issues in this field preclude strong conclusions, which future research must address, as well as considering the influence of further vulnerability factors on genotype effects. (JINS, 2016, 23, 239–253)

Keywords

Cognitive agingMiddle-agedNeuroimagingAlzheimer diseaseMemoryExecutive function
Type
Critical Reviews
Information
Journal of the International Neuropsychological Society , Volume 23 , Issue 3 , March 2017 , pp. 239 - 253
Copyright
Copyright © The International Neuropsychological Society 2016 

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